Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HB FULLER HARDENER ZT-50*************OBSOLETE**********

NFPA

PRODUCT USE

Hardener.

SYNONYMS

"5-hydroxymethyl-1-aza-3, 7-dioxabicyclo[3.3.0]octane", "5-hydroxymethyl-1-aza-3, 7-
dioxabicyclo[3.3.0]octane", oxazolidine

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

May cause SENSITIZATION by inhalation and skin contact.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Considered an unlikely route of entry in commercial/industrial environments.  

EYE

  There is some evidence to suggest that this material can causeeye irritation and damage in some persons.  Because of their alkaline nature eye contact with oxazolidines may produces moderate to severe irritation depending on the duration of contact.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Oxazolidines generally do not produce systemic harmful following skin contact but, because of their alkaline nature, may produce moderate to severe irritation. Dermal reactions may include necrosis, sloughing and scab formation.  

INHALED

  There is some evidence to suggest that this material, if inhaled, can irritate the throat and lungs of some persons.  Although inhalation is not thought to produce harmful effects, the material may still produce health damage, especially where pre-existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally confined to doses producing mortality (death) rather than those producing morbidity (disease, ill-  health).  Inhalation hazard is increased at higher temperatures.  

CHRONIC HEALTH EFFECTS

  Inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population.  

  Principal routes of exposure are by accidental skin and eye contact and by inhalation of vapors especially at higher temperatures.  Although oxazolidines are able to cross-link with dermal proteins, there is no indication,  at present, that they are dermal sensitisers.  Oral teratology studies indicate that foetal toxicity occurs occurs at maternally toxic doses but that birth defects are not a feature of exposure.  Oxazolidines are generally not mutagenic in a battery of tests designed to investigate this effect.  Because they occur as secondary and tertiary amines, the concomitant use of nitrates may result in the production of potentially carcinogenic N-nitrosoamines. There is no evidence available to suggest that oxazolidines constitute a class of carcinogenic substance.