Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

JUROX MOXYLAN TABLETS

NFPA

PRODUCT USE

Broad spectrum semi- synthetic penicillin used for the treatment of sensitive bacterial
infections in dogs and cats

SYNONYMS

"semisynthetic penicillin bacterial infection treatment veterinary use"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Large doses of cellulose may be administered orally as non-nutritive bulk. Doses of up to 30 g/day can be tolerated as bulk laxative. Extremely large oral doses may produce gastrointestinal disturbances.  Polysaccharides are not substantially absorbed from the gastrointestinal tract but may produce a laxative effect. Larger doses may produce intestinal obstruction or stomach concretions.Large quantities of the substituted polysaccharide, methylcellulose (as with other bulk laxatives), may temporarily increase flatulence. Oesophageal obstruction, by swelling, may occur if the material is swallowed dry.Doses of 3-9 gm hydroxypropylcellulose, fed to human subjects, at least one week apart, were eliminated within 96 hours. Animals fed on diets containing 3% or less, experienced no adverse effects. Higher levels produced malnutrition due to excessive bulk but caused no organic damage. In one dog, an oral dose of hydroxypropylcellulose produced diarrhoea and blood cell depression.Ingestion of hetastarch (hydroxyethyl amylopectin) has reportedly produced fever, chills, urticaria and salivary gland enlargement. Several of these effects may be due to contamination by other naturally occurring macromolecules extracted from the source material. Large volumes of ingested hetastarch may interfere with coagulation mechanisms and increase the risk of haemorrhage. Anaphylaxis has occurred.Infusions of dextrans may occasionally produce allergic reactions such as urticaria,hypotension and bronchospasm. Severe anaphylactic reactions may occasionally occurand death may result from cardiac and respiratory arrest. Nausea, vomiting, fever, joint pains, and flushing may also occur. Similarly, allergic reactions, sometimes severe (but rare) have been reported following ingestion or inhalation of tragacanth gums.  Penicillins can cause temporary diarrhea, nausea, heartburn and itchiness of the anus. They are fairly safe in the non-allergic. Hypersensitive patients can present with acute inflammation of the kidneys and anaphylactic shock, which can cause death within minutes. A generalized sensitivity reaction can occur in 1 to 3 weeks. This includes hives, swellings (especially of the face, lips and tissues around the mouth), redness of the skin, skin shedding, purple discoloration, extreme weakness, abdominal cramps, fever, joint pain, constriction of airways, severe asthma, chest pains, low blood pressure, cyanosis, collapse of circulation and lung swelling. Serum sickness type syndromes include enlarged spleen, joint pain and inflammation, muscle pain, general unwellness, lymph disorders and mental changes. There may be cross-sensitivity between penicillins and other members of their family, as well as cephalosporins and cephamycins.  

EYE

  There is some evidence to suggest that this material can causeeye irritation and damage in some persons.  

SKIN

  Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  

INHALED

  Inhalation may produce health damage*.  Not normally a hazard due to physical form of product.  

CHRONIC HEALTH EFFECTS

  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  

  This material contains a polymer with a functional group considered to be of low concern. Non-ring hydroxyl (-OH) groups in polymers (polyols) are not reactive, and are considered to be of low risk. Polyols occur naturally in the body and also include starch and cellulose.  Studies indicate that diets containing large amounts of non-absorbable polysaccharides, such as cellulose, might decrease absorption of calcium, magnesium, zinc and phosphorus.  There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population.  Repeated ingestion of penicillins can cause nausea and/or vomiting, stomach upset, diarrhea, sore or dry throat, and a sore or black hairy tongue. Resistance may develop for some bacteria, and there may be overgrowth of non-susceptible organisms (superinfection).  Exposure to small quantities may induce hypersensitivity reactions characterized by acute bronchospasm, hives (urticaria), deep dermal wheals (angioneurotic edema), running nose (rhinitis) and blurred vision . Anaphylactic shock and skin rash (non-thrombocytopenic purpura) may occur. An individual may be predisposed to such anti-body mediated reaction if other chemical agents have caused prior sensitization (cross-sensitivity).  One ingredient of the product has caused skin sensitization reactions, shown as localized reddening and hives, or may produce respiratory sensitization characterized by asthma-  like symptoms and runny nose.