Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

JUROX MOXYLAN RTU INJECTION

NFPA

PRODUCT USE

Broad spectrum semi- synthetic penicillin used for the treatment of sensitive bacterial
infections in cattle, pigs, dogs and cats

SYNONYMS

"semisynthetic penicillin bacterial infection treatment veterinary use"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Causes burns.
Risk of serious damage to eyes.
Possible risk of irreversible effects.
Harmful by inhalation, in contact with skin and if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual.  The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion.  Penicillins can cause temporary diarrhea, nausea, heartburn and itchiness of the anus. They are fairly safe in the non-allergic. Hypersensitive patients can present with acute inflammation of the kidneys and anaphylactic shock, which can cause death within minutes. A generalized sensitivity reaction can occur in 1 to 3 weeks. This includes hives, swellings (especially of the face, lips and tissues around the mouth), redness of the skin, skin shedding, purple discoloration, extreme weakness, abdominal cramps, fever, joint pain, constriction of airways, severe asthma, chest pains, low blood pressure, cyanosis, collapse of circulation and lung swelling. Serum sickness type syndromes include enlarged spleen, joint pain and inflammation, muscle pain, general unwellness, lymph disorders and mental changes. There may be cross-sensitivity between penicillins and other members of their family, as well as cephalosporins and cephamycins.  Some phenol derivatives can cause damage to the digestive system. If absorbed, profuse sweating, thirst, nausea, vomiting diarrhea, cyanosis, restlessness, stupor, low blood pressure, gasping, abdominal pain, anemia, convulsions, coma and lung swelling can happen followed by pneumonia. There may be respiratory failure and kidney damage. Chemical burns,  seizures and irregular heartbeat may result.  

EYE

  If applied to the eyes, this material causes severe eye damage.  The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating.  Some phenol derivatives may produce mild to severe eye irritation with redness, pain and blurred vision. Permanent eye injury may occur; recovery may also be complete or partial.  

SKIN

  Skin contact with the material may be harmful; systemic effects may resultfollowing absorption.  Skin contact with the material may produce toxic effects; systemic effectsmay result following absorption.  The material can produce chemical burns following direct contactwith the skin.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  Phenol and its derivatives can cause severe skin irritation if contact is maintained, and can be absorbed to the skin affecting the cardiovascular and central nervous system. Effects include sweating, intense thirst, nausea and vomiting, diarrhea, cyanosis, restlessness, stupor, low blood pressure, hyperventilation, abdominal pain, anemia, convulsions, coma, lung swelling followed by pneumonia. Respiratory failure and kidney damage may follow.  

INHALED

  Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be damaging to the health of the individual.  The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  Inhalation of quantities of liquid mist may be extremely hazardous, even lethal due to spasm, extreme irritation of larynx and bronchi, chemical pneumonitis and pulmonary edema.  If phenols are absorbed via the lungs, systemic effects may occur affecting the cardiovascular and nervous systems. Inhalation can result in profuse perspiration, intense thirst, nausea, vomiting, diarrhea, cyanosis, restlessness, stupor, falling blood pressure, hyperventilation, abdominal pain, anemia, convulsions, coma, swelling and inflammation of the lung. This is followed by respiratory failure and kidney damage. Phenols also cause loss of sensation and general depression at high concentrations. The toxicities of phenol derivatives vary.  

CHRONIC HEALTH EFFECTS

  Repeated or prolonged exposure to corrosives may result in the erosion of teeth, inflammatory and ulcerative changes in the mouth and necrosis (rarely) of the jaw. Bronchial irritation, with cough, and frequent attacks of bronchial pneumonia may ensue. Gastrointestinal disturbances may also occur. Chronic exposures may result in dermatitis and/or conjunctivitis.  There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment.  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population.  There is some evidence that human exposure to the material may result in developmental toxicity. This evidence is based on animal studies where effects have been observed in the absence of marked maternal toxicity, or at around the same dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects.  Respiratory sensitization may result in allergic/asthma like responses; from coughing and minor breathing difficulties to bronchitis with wheezing, gasping.  Repeated ingestion of penicillins can cause nausea and/or vomiting, stomach upset, diarrhea, sore or dry throat, and a sore or black hairy tongue. Resistance may develop for some bacteria, and there may be overgrowth of non-susceptible organisms (superinfection).  Exposure to small quantities may induce hypersensitivity reactions characterized by acute bronchospasm, hives (urticaria), deep dermal wheals (angioneurotic edema), running nose (rhinitis) and blurred vision . Anaphylactic shock and skin rash (non-thrombocytopenic purpura) may occur. An individual may be predisposed to such anti-body mediated reaction if other chemical agents have caused prior sensitization (cross-sensitivity).