Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

JUROX LUTOGESTON INJECTION

NFPA

PRODUCT USE

Injection for the treatment of habitual abortion in dogs, cows, horses, pigs, sheep and
goats

SYNONYMS

"habitual abortion treatment veterinary use"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Irritating to skin.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  The material has NOT been classified as "harmful by ingestion". This is because of the lack of corroborating animal or human evidence. The material may still be damaging to the health of the individual, following ingestion, especially where pre-existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, unintentional ingestion is not thought to be cause for concern.  

EYE

  Limited evidence or practical experience suggests, that the material may cause eye irritation in a substantial number of individuals. Prolonged eye contact may cause inflammation characterized by a temporary redness of the conjunctiva (similar to windburn).  The material may be irritating to the eye, with prolonged contact causing inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.  

SKIN

  Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.  The material may cause moderate inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  The material may cause severe skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin. Repeated exposures may produce severe ulceration.  

INHALED

  The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified using animal models). Nevertheless, adverse effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Not normally a hazard due to non-volatile nature of product.  

CHRONIC HEALTH EFFECTS

  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  

  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population.  There is some evidence that human exposure to the material may result in developmental toxicity. This evidence is based on animal studies where effects have been observed in the absence of marked maternal toxicity, or at around the same dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects.  Exposure to the material for prolonged periods may cause physical defects in the developing embryo (teratogenesis).  Progestogens cause gastrointestinal disturbances, acne, swelling, weight gain, skin rashes, hives, menal depression, breast changes with discomfort and occasionally enlargement in males, changes in sex drive, altered menstrual cycles or irregular menstrual bleeding. Liver abnormalities and jaundice have been reported.  Some progestogens have been associated with an increase in congenital abnormalities. Repeated intake of progesterones may produce headache, nausea, vomiting, diarrhea, inflammation of the mouth cavity with ulcers, swelling, weight change, fever, fatigue, increased or decreased sleep, mental depression, allergic rashes including hives and itching, acne, sensitivity to light, pigmented skin, hair loss, excessive hair growth, clotting and vein inflammation, obstructive jaundice, and precipitation of porphyria. Other symptoms may include menstrual disorders, breast changes, effects on the cervix, Candida infections of the vagina, decreased sex drive, and inhibition of sperm production. Exposure during the first trimester may produce mild masculinization of the external genitalia of the female fetus or defects in the male. Exposure to female sex hormones during the first trimester has also been associated with various birth defects of the cardiovascular system and bones.  One ingredient of the product has caused skin sensitization reactions, shown as localized reddening and hives, or may produce respiratory sensitization characterized by asthma-  like symptoms and runny nose.