Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

JUROX UTOZYME FOAMING PESSARIES

NFPA

PRODUCT USE

Pessary for the post- natal treatment of infections, cleaning of the uterus, retained
placenta and metritis of cattle, sheep, goats, pigs and horses

SYNONYMS

"pessary post natal treatment uterus cleaning retained placenta metritis", "veterinary
use cattle sheep"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  The material has NOT been classified as "harmful by ingestion". This is because of the lack of corroborating animal or human evidence. The material may still be damaging to the health of the individual, following ingestion, especially where pre-existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, unintentional ingestion is not thought to be cause for concern.  

EYE

  Limited evidence or practical experience suggests, that the material may cause eye irritation in a substantial number of individuals. Prolonged eye contact may cause inflammation characterized by a temporary redness of the conjunctiva (similar to windburn).  The material may be irritating to the eye, with prolonged contact causing inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.  

SKIN

  There is some evidence to suggest that the material may cause mild but significant inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  

CHRONIC HEALTH EFFECTS

  There is some evidence that human exposure to the material may result in developmental toxicity. This evidence is based on animal studies where effects have been observed in the absence of marked maternal toxicity, or at around the same dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects.  Ample evidence exists that developmental disorders are directlycaused by human exposure to the material.  Repeated or prolonged exposures to tetracyclines can cause sore throat, hoarseness, a black hairy tongue, bulky loose stools, fat in the feces, inflammation of the mouth cavity, difficulty swallowing, damage to the anogenital area and ulcers of the esophagus. Deposits in the eye may cause abnormal pigmentation of the conjunctivae. Tetracyclines can interfere with vitamin K function and impair blood clotting. They are deposited in the bones. If pregnant women take them, they can interfere with bone growth of the fetus. Hypersensitivity reactions include burning of the eyes, conjunctivitis, spotty and red rashes, dermatitis with sloughing, hives, itching, swollen cracked lips, an inflamed tongue, fever, asthma, fatty liver, blockage of bile, loss of platelets, neutrophils, white blood cells or all blood cells, swelling due to blood vessels and nerves, inflammation of the membranous sac surrounding the heart, exacerbation of lupus, anaphylactic shock and skin rash due to capillary bleeds. Other signs and symptoms include lung infiltrates, diabetes, temporary muscle disorders, blood poisoning, psychotic reactions and fatal liver damage. Sensitivity to light aggravated by sunlight may occur. Loosening and pigmentation of the nails may occur at the same time. Increased pressure in the head can cause swelling of the optic nerve, headache, vision impairment, and bleeding from the retina, especially in children. Pregnant women seem to be most susceptible to liver damage caused by tetracyclines. Jaundice followed by uremia, acidosis and irreversible shock is usual. Tetracyclines are secreted in the breast milk and readily cross the placenta to affect the fetus. The fetus will show retardation of skeletal development and underdevelopment of the enamel of the teeth. Long-term use of oxytetracyclines often results in kidney damage and failure, with increased urinary output, extreme thirst, protein in the urine, acidosis, sugar and excess amino acids in the urine.