Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

JUROX COBALEX INJECTION (NZ)

NFPA

PRODUCT USE

For the treatment and control of cobalt and vitamin B12 deficiencies in sheep and cattle

SYNONYMS

"cobalt deficiency treatment vitamin B12 deficiency treatment veterinary use"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Causes burns.
Risk of serious damage to eyes.
Possible risk of irreversible effects.
Harmful: danger of serious damage to health by prolonged exposure through
inhalation, in contact with skin and if swallowed.
Toxic by inhalation, in contact with skin and if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual.  The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion.  Some phenol derivatives can cause damage to the digestive system. If absorbed, profuse sweating, thirst, nausea, vomiting diarrhea, cyanosis, restlessness, stupor, low blood pressure, gasping, abdominal pain, anemia, convulsions, coma and lung swelling can happen followed by pneumonia. There may be respiratory failure and kidney damage. Chemical burns,  seizures and irregular heartbeat may result.  Cobalamins are absorbed from the gastrointestinal tract but may be irregularly absorbed when given in large therapeutic doses. Absorption is impaired in the absence of Castles Intrinsic Factor. Cobalamins are stored in the liver, excreted in the bile and undergo some hepatoenteric recirculation; part of the dose is excreted in the urine.  

EYE

  If applied to the eyes, this material causes severe eye damage.  The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating.  

SKIN

  Skin contact with the material may produce toxic effects; systemic effectsmay result following absorption.  The material can produce chemical burns following direct contactwith the skin.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  Phenol and its derivatives can cause severe skin irritation if contact is maintained, and can be absorbed to the skin affecting the cardiovascular and central nervous system. Effects include sweating, intense thirst, nausea and vomiting, diarrhea, cyanosis, restlessness, stupor, low blood pressure, hyperventilation, abdominal pain, anemia, convulsions, coma, lung swelling followed by pneumonia. Respiratory failure and kidney damage may follow.  

INHALED

  Not normally a hazard due to non-volatile nature of product.  Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be damaging to the health of the individual.  The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  Inhalation of quantities of liquid mist may be extremely hazardous, even lethal due to spasm, extreme irritation of larynx and bronchi, chemical pneumonitis and pulmonary edema.  If phenols are absorbed via the lungs, systemic effects may occur affecting the cardiovascular and nervous systems. Inhalation can result in profuse perspiration, intense thirst, nausea, vomiting, diarrhea, cyanosis, restlessness, stupor, falling blood pressure, hyperventilation, abdominal pain, anemia, convulsions, coma, swelling and inflammation of the lung. This is followed by respiratory failure and kidney damage. Phenols also cause loss of sensation and general depression at high concentrations. The toxicities of phenol derivatives vary.  

CHRONIC HEALTH EFFECTS

  Repeated or prolonged exposure to corrosives may result in the erosion of teeth, inflammatory and ulcerative changes in the mouth and necrosis (rarely) of the jaw. Bronchial irritation, with cough, and frequent attacks of bronchial pneumonia may ensue. Gastrointestinal disturbances may also occur. Chronic exposures may result in dermatitis and/or conjunctivitis.  There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment.  There is some evidence that human exposure to the material may result in developmental toxicity. This evidence is based on animal studies where effects have been observed in the absence of marked maternal toxicity, or at around the same dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects.  Long-term exposure to phenol derivatives can cause skin inflammation, loss of appetite and weight, weakness, muscle aches and pain, liver damage, dark urine, loss of nails, skin eruptions, diarrhea, nervous disorders with headache, salivation, fainting, discoloration of the skin and eyes, vertigo and mental disorders, and damage to the liver and kidneys.  Though the cobalamins are generally well tolerated, allergic hypersensitivity reactions have followed the administration of the Vitamin B12 factors, cyanocobalamin and hydroxocobalamin. Vitamin B12 rapidly increases the rate of cell maturation, in vivo, and as a consequence increases the rate of nucleic acid degradation which in turn increases blood uric acid levels; this may produce gout in susceptible individuals.