Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

QUINOLINE YELLOW, SPIRIT SOLUBLE

NFPA

PRODUCT USE

Synthetic dye used in spirit- based lacqueurs, polystyrenes, polycarbonates, polyamides
and acrylic resins, coloured smokes, and hydrocarbon solvents. Approved for use in
externally applied drugs and cosmetics.

SYNONYMS

C18-H11-N-O2, C18-H11-N-O2, "quinonaphthalone (2-(2-quinolinyl)-1H-indene-1, 3-(2H)-
dione", "quinonaphthalone (2-(2-quinolinyl)-1H-indene-1, 3-(2H)-dione", "C.I. 47000",
"Arlosol Yellow S", "Chinoline yellow S (soluble in spirits)", "Chinoline Yellow ZSS",
"D&C Yellow No. 11", "Nitro Fast Yellow SL", "Oil Yellow SIS", "Petrol Yellow C",
"Quinoline Yellow base", "Quinoline Yellow SS", "Waxoline Yellow T", "Yellow 204"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

None

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's edema. The pathogenesis of contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the delayed type. Other allergic skin reactions, e.g. contact urticaria, involve antibody-mediated immune reactions. The significance of the contact allergen is not simply determined by its sensitization potential: the distribution of the substance and the opportunities for contact with it are equally important. A weakly sensitizing substance which is widely distributed can be a more important allergen than one with stronger sensitizing potential with which few individuals come into contact. From a clinical point of view, substances are noteworthy if they produce an allergic test reaction in more than 1% of the persons tested.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are usually by skin contact/eye contact inhalation of generated dust.  There is some evidence that the substance may show carcinogenic activity  in male F344/N rats based on increased incidences of hepatocellular  adenoma, renal tubule neoplasms, and squamous cell neoplasms of the oral  cavity and in female F344/N rats based on increased incidences of  hepatocellular neoplasms. Incidences of uncommon squamous cell carcinoma  in the oral cavity in females may be related to chemical treatment.  Exposure of rats to the material in feed for two years resulted in  increased incidences of non-neoplastic liver lesions including clear cell  foci, increased basophilia and granularity in the cytoplasm of  hepatocytes, and bile duct, hepatocyte, and Kupffer cell pigmentation in  males and females and mixed cell foci in males. In the kidney there were  increased incidences of renal tubule pigmentation and transitional  epithelial hyperplasia in males and females and renal tube hyperplasia in  males. The severity of nephropathy was increased in exposed males and  females.  NTP Technical Report Series No.463, April 1997