Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

VINYL CYCLOHEXENE DIOXIDE

NFPA

PRODUCT USE

Used in polymers and organic synthesis. Intermediate

SYNONYMS

C8-H12-O2, "vinylcyclohexane dioxide", "1, 2-epoxy-4-(epoxyethyl)cyclohexane", "1, 2-
epoxy-4-(epoxyethyl)cyclohexane", "1-epoxyethyl-3, 4-epoxycyclohexane", "1-epoxyethyl-3,
4-epoxycyclohexane", "3-(1, 2-epoxyethyl)-7-oxabicyclo(4.1.0)heptane", "3-(1, 2-
epoxyethyl)-7-oxabicyclo(4.1.0)heptane", 4-(epoxyethyl)-7-oxabicyclo(4.1.0)heptane, 4-
(epoxyethyl)-7-oxabicyclo(4.1.0)heptane, "1-ethyleneoxy-3, 4-epoxycyclohexane", "1-
ethyleneoxy-3, 4-epoxycyclohexane", 3-oxiranyl-7-oxabicyclo(4.1.0)heptene, 3-oxiranyl-7-
oxabicyclo(4.1.0)heptene, "vinylcyclohexene diepoxide", "4-vinylcyclohexene diepoxide",
"4-vinylcyclohexene diepoxide", "4-vinyl-1-cyclohexene diepoxide", "4-vinyl-1-cyclohexene
diepoxide", "4-vinyl-1, 2-cyclohexene diepoxide", "4-vinyl-1, 2-cyclohexene diepoxide",
"1-vinyl-3-cyclohexene dioxide", "1-vinyl-3-cyclohexene dioxide", "4 vinylcyclohexene
dioxide", "4-vinyl-1-cyclohexene dioxide", "4-vinyl-1-cyclohexene dioxide", "7-
oxabicyclo(4.1.0)heptane, 3-(epoxyethyl)-", "7-oxabicyclo(4.1.0)heptane, 3-(epoxyethyl)-
", "Ucet Textile Finish 11-74 (obs.)", "Ucet Textile Finish 11-74 (obs.)", NCI-C60139

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Irritating to skin.
Limited evidence of a carcinogenic effect.
Possible risk of irreversible effects.
Toxic by inhalation, in contact with skin and if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual.  

EYE

  Although the liquid is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  Skin contact with the material may produce toxic effects; systemic effectsmay result following absorption.  Open cuts, abraded or irritated skin should not be exposed to this material.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  The material may cause moderate inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering.  

INHALED

  Inhalation of aerosols (mists, fumes), generated by the material during the course of normal handling, may produce toxic effects; these may be fatal.  Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by narcosis, reduced alertness, loss of reflexes, lack of coordination and vertigo.  There is some evidence to suggest that the material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  Inhalation hazard is increased at higher temperatures.  Inhalation of high concentrations of gas/vapor causes lung irritation with coughing and nausea, central nervous depression with headache and dizziness, slowing of reflexes, fatigue and inco-ordination.  

CHRONIC HEALTH EFFECTS

  There has been concern that this material can cause cancer or mutations, but there is not enough data to make an assessment.  Exposure to the material may result in a possible risk of irreversible effects. The material may produce mutagenic effects in man. This concern is raised, generally, on the basis ofappropriate studies using mammalian somatic cells in vivo. Such findings are often supported by positive results from in vitro mutagenicity studies.  Several studies have demonstrated the carcinogenicity of VCD with induction of tumours both at the site of application and at sites distant from the initial contact. Squamous cell carcinomas and sarcomas were produced after topical application to mice. There is clear evidence of carcinogenicity for male and female rats based on significant increases in squamous cell and basal cell papillomas and carcinomas of the skin.  An increased incidence of lung neoplasms in female mice considered to result from metastasis of ovarian cancer to the lung and/or a VCD-related increase in alveolar/bronchiolar adenoma and carcinoma was considered to be related to topical application.