Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

QUEST FRAGRANCE COMPOUND A923494

NFPA

PRODUCT USE

Fragrance compound.

SYNONYMS

"fragrance compound Piko Two", "Manufacturer's Code: PA 0258 Picko 2 (misspelling) Piko-2"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful to aquatic organisms, may cause long- term adverse effects in the
aquatic environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be damaging to the health of the individual.  The toxicity of phthalates is not excessive due to slow oral absorption and metabolism. Absorption is affected by fat in the diet. Repeated doses can cause cumulative toxic effects, and symptoms include an enlarged liver which often reverses if exposure is maintained. Carbohydrate metabolism is disrupted, and cholesterol and triglyceride levels in the blood falls. There can also be withering of the testicles. Some phthalates can increase the effects of antibiotics, thiamine (vitamin B1) and sulfonamides.  

EYE

  Although the liquid is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  

INHALED

  The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified using animal models). Nevertheless, adverse effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Not normally a hazard due to non-volatile nature of product.  

CHRONIC HEALTH EFFECTS

  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment.  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population.  Exposure to phthalates over years leads to pain, numbness and spasms in the hands and feet. Many people have developed multiple disorders in the nervous system and the balancing system. Levels of sex hormones are reduced in women, leading to missed ovulations and miscarriages. They also reduce sperm counts and fertility in men. They mimic certain sex hormones and can damage the fetus. Phthalates are found in paints, inks and glues.  Polycyclic aromatic hydrocarbons are found in a number of materials such as coal tar, tobacco smoke, petroleum and air pollution. Some substituted derivatives have been identified as extremely liable to cause cancer, especially that of the lung and genito-  urinary tract. Some jurisdictions required that health surveillance be conducted on workers occupationally exposed to PHAs.  Intolerance to perfumes, by inhalation, may occur if the perfume contains a sensitising principal. Symptoms may vary from general illness, coughing, phlegm, wheezing, chest-  tightness, headache, exertional dyspnoea, acute respiratory illness, hayfever, and other respiratory diseases (including asthma). Perfumes can induce hyper-reactivity of the respiratory tract without producing an IgE-mediated allergy or demonstrable respiratory obstruction. This was shown by placebo-controlled challenges of nine patients to "perfume mix". The same patients were also subject to perfume provocation, with or without a carbon filter mask, to ascertain whether breathing through a filter with active carbon would prevent symptoms. The patients breathed through the mouth, during the provocations, as a nose clamp was used to prevent nasal inhalation. The patient's earlier symptoms were verified; breathing through the carbon filter had no protective effect. The symptoms were not transmitted via the olfactory nerve but they may have been induced by trigeminal reflex via the respiratory tract or by the eyes.  Cases of occupational asthma induced by perfume substances such as isoamyl acetate, limonene, cinnamaldehyde and benzaldehyde, tend to give persistent symptoms even though the exposure is below occupational exposure limits.  Inhalation intolerance has also been produced in animals. The emissions of five fragrance products, for one hour, produced various combinations of sensory irritation, pulmonary irritation, decreases in expiratory airflow velocity as well as alterations of the functional observational battery indicative of neurotoxicity in mice. Neurotoxicity was found to be more severe after mice were repeatedly exposed to the fragrance products, being four brands of cologne and one brand of toilet water.