Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HEXAHYDRO-1,3,5-TRIETHYL-S-TRIAZINE

NFPA

PRODUCT USE

Reagent. Rubber accelerator. Fungicide

SYNONYMS

C9-H21-N3, "s-triazine, hexahydro-1, 3, 5-triethyl-", "s-triazine, hexahydro-1, 3, 5-
triethyl-", "Vancide TH"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Toxic by inhalation.
Causes severe burns.
Risk of serious damage to eyes.
Harmful in contact with skin and if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  The material can produce severe chemical burns within the oral cavity and gastrointestinal tract following ingestion.  Triazine derivatives have been shown to cause structural damage to theliver in animal studies.  

EYE

  The material can produce severe chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating.  If applied to the eyes, this material causes severe eye damage.  The material may produce severe irritation to the eye causing pronounced inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.  

SKIN

  Skin contact with the material may be harmful; systemic effects may resultfollowing absorption.  The material can produce severe chemical burns following direct contactwith the skin.  Toxic effects may result from skin absorption.  

INHALED

  If inhaled, this material can irritate the throat andlungs of some persons.  Not normally a hazard due to non-volatile nature of product.  Inhalation of vapor is more likely at higher than normal temperatures.  Inhalation of vapor may aggravate a pre-existing respiratory condition.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are by accidental skin and eye contact and by inhalation of vapors especially at higher temperatures.  No human exposure data available. For this reason health effects described are based on experience with chemically related materials.  The substance induced dose-related increases in unscheduled DNA synthesis  in rat primary hepatocytes exposed at nine different dose levels (ranging  from 0.00003-0.1 u/ml). The was a significant increase in the mean number  of net nuclear grains, an increase of at least 5 counts over the solvent  control at 0.06 ul/ml.  Male and female rats IRC mice given single doses of the substance by oral  gavage (25, 125 and 225 mg/kg) showed no significant increase in the  number of micronucleated polychromatic erythrocytes at 24, 48 and 72 hours  after administration.  In a developmental toxicity study with rats the substance was administered  by gavage at 10, 75 and 150 mg/kg; no teratogenic effects were  demonstrated. The no-observed-effect-level (NOEL) was 75 mg/kg and the  lowest-observed-effect-level (LOEL)was 150 mg/kg