Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

RENIN

NFPA

PRODUCT USE

Proteolytic enzyme produced and secreted by the kidney. Also occurs in amniotic fluid.
Exists in alpha- , beta and gamma configurations Observed in high molecular weight
inactive forms which decrease in size upon acid treatment and become active. Secreted by
the juxtaglomerular cells and acts upon the plasma substrate angiotensinogen to split off
an inactive decapeptide, angiotensin I, which is subsequently converted to the active
pressor agent angiotensin II. Secretion of renin is stimulated by constriction of the
renal artery, blood loss, low sodium levels and adrenal insufficiency. Pregnancy produces
increased levels.

SYNONYMS

"proteolytic enzyme", "angiotensinogen / angiotensin enzyme activator"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Considered an unlikely route of entry in commercial/industrial environments.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  The dust may produce eye discomfort causing smarting, pain and redness.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  

CHRONIC HEALTH EFFECTS

  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  

  Principal routes of exposure are usually by inhalation of generated dust and skin contact.  Dusts produced by enzymes can attack the respiratory system. Allergic asthma produced after exposure includes spasm, cough and wheezing. Other symptoms include chronic cough, phlegm, fever, muscle pains, fatigue, airway obstruction, and scarring at the top or base of the lungs. There may also be abdominal pain, headache, stomach-ache and a general feeling of unwellness. Prolonged contact can result in skin soreness, redness, inflammation and possible ulceration. There may also be loss of lung function due to scarring.