Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

VANDERBILT BUTYL EIGHT

NFPA

PRODUCT USE

Antioxidant.

SYNONYMS

"dithiocarbamate in propyl cellosolve"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

May form explosive peroxides.
Harmful if swallowed.
May cause SENSITIZATION by skin contact.
Flammable.
Toxic to aquatic organisms, may cause long- term adverse effects in the aquatic
environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Considered an unlikely route of entry in commercial/industrial environments.  The toxic effects of mercaptobenzothiole is mainly due to the high concentration of thiocarbamates which are produced as a metabolite. Although fairly safe in low doses, if enough substance is given, symptoms such as loss of appetite, squinting, excessive salivation and tears, hair standing up, inco-ordination, hypothermia, depression, paralysis, and muscle twitching. Very high doses cause a progressing weakness and rising paralysis eventually affecting the muscles of breathing and causing death. Other symptoms such as flushing, breathing difficulties, nausea, vomiting and low blood pressure may also occur if alcohol is also given.  

EYE

  There is some evidence to suggest that this material can causeeye irritation and damage in some persons.  The liquid may produce eye discomfort and is capable of causing temporary impairment of vision and/or transient eye inflammation, ulceration.  The vapour when concentrated has pronounced eye irritation effects and this gives some warning of high vapour concentrations. If eye irritation occurs seek to reduce exposure with available control measures, or evacuate area.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Bare unprotected skin should not be exposed to this material.  The material may accentuate any pre-existing dermatitis condition.  

INHALED

  Inhalation may produce health damage*.  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of the material, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  Inhalation hazard is increased at higher temperatures.  Acute effects from inhalation of high vapor concentrations may be chest and nasal irritation with coughing, sneezing, headache and even nausea.  If exposure to highly concentrated solvent atmosphere is prolonged this may lead to narcosis, unconsciousness, even coma and possible death.  

CHRONIC HEALTH EFFECTS

  Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population.  

  Principal routes of exposure are usually by skin contact with the material and inhalation of vapor.  Ethylene glycol esters and their ethers cause wasting of the testicles, reproductive changes, infertility and changes to kidney function. Shorter chain compounds are more dangerous. They are also associated with the formation of stones in the urine.  Repeated exposure to high concentrations may cause damage to bone marrow  and blood cells, kidneys.  Signs and symptoms of damage to bone marrow / blood cells include easy  tiring and pallor, decreased resistance to disease and excessive bruising  and bleeding.  Propoxyethanol may produce adverse effects on red blood cells with  possible secondary effects on the spleen, liver and kidney.  Symptoms of kidney damage include changes in urine appearance and output  or oedema.  When 2-MBT was administered by gavage as daily oral doses of 100 mg/kg to  two strains of mice from 7 to 28 days of age followed by dietary  administration of this dosage for the remainder of the study (18 months)  or by single subcutaneous injection of 215 mg/kg or 1000 mg/kg at 28 days  of age there was an increase in reticular cell sarcomas at the sites of  injection in one strain of mice dosed subcutaneously at 215 mg/kg or daily  in the diet.  Two strains of mice given 2-MBT at a dosage of 464 mg/kg by subcutaneous  injection on days 6 through 15 of gestation showed an increased incidence  of foetal malformations at maternally toxic doses.  When administered by gavage at 200 mg/kg 2-MBT to rats on days 4 and 11 of  gestation there was an increased level of fatalities in foetuses. No  evidence of teratogenic activity or embryolethality was reported in  another study when the substance was administered at a dose of 200 mg/kg  2-MBT in corn oil by intraperitoneal injection on days 1 through 15 of  gestation. No mutagenic effects were demonstrated in the L5178Y TK mouse  lymphoma mutation assay and in microbial mutagenicity assays (either with  or without mammalian microsomal activation). A further study showed one  equivocal positive finding in one Salmonella strain in one assay.  No evidence of genotoxic activity was found in either the CHO/HGPRT cell  point mutation or BALB/C3t3 cell transformation assays. A micronucleus  assay performed in CD-1 mice at a dose level of 300 mg/kg 2-MBT did not  produce evidence of clastogenic activity. A weak positive response occurred  at highly cytotoxic doses in the L5178Y TK mouse lymphoma assay. [Monsanto]  Mercaptobenzothiazole can cause liver damage, birth defects, cancers and reduction in male fertility, probably due to formation of dithiocarbamate, a metabolite.