Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

VINYLTRI(METHYLETHYLKETOXIME)SILANE

NFPA

PRODUCT USE

Silicone monomer.

SYNONYMS

C14-H27-N3-O3-Si, "2-butanone, o, o"", o'""-(ethenylsilylidyne)trioxime", "2-butanone,
o, o"", o'""-(ethenylsilylidyne)trioxime", "o, o', o'""-(ethenylsilylidene)trioxime 2-
butanone", "o, o', o'""-(ethenylsilylidene)trioxime 2-butanone", "o, o', o'""-
(vinylsilylidyne)trioxime 2-butanone", "o, o', o'""-(vinylsilylidyne)trioxime 2-butanone",
vinyltris(2-butanoneoximato)silane, vinyltrioxime, "vinyl tris(butanone oxime) silane",
"vinyl oximinosilane", "oxime silane"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

May form explosive peroxides.
Risk of serious damage to eyes.
Flammable.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Ingestion may result in nausea, pain, vomiting. Vomit entering the lungs by aspiration may cause potentially lethal chemical pneumonitis.  

EYE

  If applied to the eyes, this material causes severe eye damage.  The vapour when concentrated has pronounced eye irritation effects and this gives some warning of high vapour concentrations. If eye irritation occurs seek to reduce exposure with available control measures, or evacuate area.  Risk of serious damage to eyes.  

SKIN

  Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.  The material is not thought to be a skin irritant (as classified using animal models). Temporary discomfort, however, may result from prolonged dermal exposures. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Toxic effects may result from skin absorption.  The material may accentuate any pre-existing skin condition.  The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.  Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's edema. The pathogenesis of contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the delayed type. Other allergic skin reactions, e.g. contact urticaria, involve antibody-mediated immune reactions. The significance of the contact allergen is not simply determined by its sensitization potential: the distribution of the substance and the opportunities for contact with it are equally important. A weakly sensitizing substance which is widely distributed can be a more important allergen than one with stronger sensitizing potential with which few individuals come into contact. From a clinical point of view, substances are noteworthy if they produce an allergic test reaction in more than 1% of the persons tested.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Inhalation of vapor may aggravate a pre-existing respiratory condition.  Inhalation hazard is increased at higher temperatures.  Inhalation of vapor may result in nausea, headache.  Central nervous system (CNS) depression may include general discomfort, symptoms of giddiness, headache, dizziness, nausea, anaesthetic effects, slowed reaction time, slurred speech and may progress to unconsciousness. Serious poisonings may result in respiratory depression and may be fatal.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are by accidental skin and eye contact and by inhalation of vapors especially at higher temperatures.  The hydrolysis product, MEKO, administered to rats by gavage at 25, 75  and 225 mg/kg/day, 7 days/week for 13 weeks, produced dose-related  decreases in red blood cell counts and haemoglobin and haematocrit values  accompanied by a mild to marked reticulocytosis (increased number of young  red blood cells).  Other effects included a dose-related pattern of spleen, liver and kidney  weights. The spleen and liver showed evidence of compensatory red blood  cell production suggesting that, in the rat, MEKO induces haemolytic  anaemia with complementary erythropoiesis. A no-observed-effect-level was  not established but effects at 25 mg/kg were described as minimal.  When MEKO was administered to rats at dose levels of 0.5, and  1.0 ml/kg/day, daily for 4 weeks, transient central nervous system  depression immediately followed. At 4 weeks dose-related decreases were  seen in red blood cell count and haemoglobin. Dose-related increases were  evident in spleen weight (from 1.7 to 3.2 fold). It was concluded that  0.1 ml/kg produced only minimal effects.  When rats were exposed by inhalation to MEKO vapour for 6 hours/day,  5 days/week for 4 weeks, mild increases in blood mean corpuscular volume,  mean corpuscular haemoglobin, reticulocyte count and red blood cell count  were seen at 533 and 714 ppm. Spleen weights were increased and  haemosiderosis (deposits of iron) in the spleen were seen at 714 ppm.  Haemosiderosis probably resulted from red blood cell haemolysis. Exposures  at 60 and 283 ppm produced no observed effects.  An increased incidence of liver tumours was observed microscopically in  male mice exposed to 375 ppm for 18 months. Both male and female mice  exposed at 375 ppm showed enlarged livers but tumours did not occur in  females.