Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

YATES CAPTAN

NFPA

PRODUCT USE

Seed treatment, fungicide in paints, plastics, leather, fabrics and fruit preservation,
bacteriostat.

SYNONYMS

C9-H8-Cl3-N-O2-S, C9-H8-Cl3-N-O2-S, "3a, 4, 7, 7a-tetrahydro-N-
(trichloromethanesulphenyl)phthalimide", "3a, 4, 7, 7a-tetrahydro-N-
(trichloromethanesulphenyl)phthalimide", "1, 2, 3, 6-tetrahydro-N-
(trichloromethylthio)phthalimide", "1, 2, 3, 6-tetrahydro-N-
(trichloromethylthio)phthalimide", "N-trichloromethylmercapto-4-cyclohexene-1, 2-
dicarboximide", "N-trichloromethylmercapto-4-cyclohexene-1, 2-dicarboximide", "N-
(trichloromethylmercapto)-delta(sup 4)-tetrahydrophthalimide", "N-
(trichloromethylmercapto)-delta(sup 4)-tetrahydrophthalimide", "N-
trichloromethylthiocyclohex-4-ene-1, 2-dicarboximide", "N-trichloromethylthiocyclohex-4-
ene-1, 2-dicarboximide", "N-trichloromethylthio-cis-delta(sup 4)-cyclohexene-1, 2-
dicarboximide", "N-trichloromethylthio-cis-delta(sup 4)-cyclohexene-1, 2-dicarboximide",
"N-((trichloromethyl)thio)-4-cyclohexene-1, 2-dicarboximide", "N-((trichloromethyl)thio)-
4-cyclohexene-1, 2-dicarboximide", "trichloromethylthio-1, 2, 5, 6-tetrahydrophthalamide",
"trichloromethylthio-1, 2, 5, 6-tetrahydrophthalamide", N-
((trichloromethyl)thio)tetrahydrophthalimide, N-
((trichloromethyl)thio)tetrahydrophthalimide, "N-trichloromethylthio-3a, 4, 7, 7a-
tetrahydrophthalimide", "N-trichloromethylthio-3a, 4, 7, 7a-tetrahydrophthalimide", "4-
cyclohexene-1, 2-dicarboximide, N-(trichloromethyl)thio-", "4-cyclohexene-1, 2-
dicarboximide, N-(trichloromethyl)thio-"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Toxic by inhalation.
Irritating to skin.
Risk of serious damage to eyes.
May cause SENSITIZATION by skin contact.
Limited evidence of a carcinogenic effect.
Very toxic to aquatic organisms.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Considered an unlikely route of entry in commercial/industrial environments.  

EYE

  If applied to the eyes, this material causes severe eye damage.  

SKIN

  This material can cause inflammation of the skin oncontact in some persons.  Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions.  The material may accentuate any pre-existing skin condition.  Open cuts, abraded or irritated skin should not be exposed to this material.  The material may cause severe skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin. Repeated exposures may produce severe ulceration.  The material may cause severe skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin. Repeated exposures may produce severe ulceration.  Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's edema. The pathogenesis of contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the delayed type. Other allergic skin reactions, e.g. contact urticaria, involve antibody-mediated immune reactions. The significance of the contact allergen is not simply determined by its sensitization potential: the distribution of the substance and the opportunities for contact with it are equally important. A weakly sensitizing substance which is widely distributed can be a more important allergen than one with stronger sensitizing potential with which few individuals come into contact. From a clinical point of view, substances are noteworthy if they produce an allergic test reaction in more than 1% of the persons tested.  

INHALED

  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of the material, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  There has been concern that this material can cause cancer or mutations, but there is not enough data to make an assessment.  Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population.  

  Principal routes of exposure are by accidental skin and eye contact andinhalation of generated dusts.  The dust may cause irreversible eye damage on prolonged contact.  When mice were administered captan in the diet both sexes showed a  statistically significant incidence of duodenal tumours. This response  was not elicited in rats of either sex.  In mammals the three chlorine atoms are cleaved under the influence of  cellular sulfhydryl compounds. Trithiocarbamate, thiophosgene, and  tetrahydrophthalimide (THPI) are also formed. THPI is further degraded to  tetrahydrophthalimidic acid and further to phthalic acid and ammonia.