Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HYODEOXYCHOLIC ACID

NFPA

PRODUCT USE

Occurs in bile of animals where it is secreted into gut to assist in the emulsification of
fats and other water- insoluble substances. Used as a solubilising agent in the
manufacture of vaccines. Forms molecular coordination compounds with many substances (so-
called choleic acids).

SYNONYMS

C24-H40-O4, "5-beta-cholan-24-oic acid, 3alpha, 6alpha-dihydroxy-", "5-beta-cholan-24-
oic acid, 3alpha, 6alpha-dihydroxy-", "5beta-cholanic acid-3alpha, 6alpha-diol", "3alpha,
6alpha-dihydroxy-5beta-cholan-4-oic acid", "3alpha, 6alpha-dihydroxy-5beta-cholan-4-oic
acid", "6alpha-hydroxylithocholic acid", "alpha-hyodeoxycholic acid", "hyodesoxycholic
acid"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

None

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Considered an unlikely route of entry in commercial/industrial environments.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Not normally a hazard due to non-volatile nature of product.  High concentrations cause inflamed airways and watery swellingof the lungs with edema.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are usually by skin contact and inhalation of generated dust.  Mice given intramuscular injections of deoxycholic acid solutions  were found to develop a statistically significant number of pulmonary  adenomas (benign epithelial tumours). Intravenous or oral administration  of the substance results in a decrease in the total glycolytic activity of  and pathological damage to the liver.