Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

LEPIDINE

NFPA

PRODUCT USE

Organic preparations, medicines.

SYNONYMS

C10-H9-N, C9H6NCH3, 4-methylquinoline, 4-methylquinoline, lepidin, cincholepidine, 4-
lepidine, 4-lepidine, gamma-methylquinoline, "quinoline, 4-methyl-", "quinoline, 4-
methyl-"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful if swallowed.
Limited evidence of a carcinogenic effect.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Exposure to alkylpyridines (including the picolines) may result in an alteration to the heart beat, either speeding it up or slowing it down.  

EYE

  There is some evidence to suggest that this material can causeeye irritation and damage in some persons.  Pyridine and its derivatives generally produce local irritation oncontact with the cornea.  

SKIN

  Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.  There is some evidence to suggest that this material can cause inflammation of the skin on contact in some persons.  Open cuts, abraded or irritated skin should not be exposed to this material.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  Pyridine and derivatives cause local irritation on skin; absorption through the skin can cause similar effects as inhalation.  

INHALED

  Inhalation may produce health damage*.  Inhalation of aerosols (mists, fumes), generated by the material during the course of normal handling, may be damaging to the health of the individual.  There is some evidence to suggest that the material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  Clinical signs of quinoline intoxication include lethargy, respiratory distress and prostration leading to coma.  Pyridine and its derivatives generally produce local irritation on contact with the mucous membranes. Overexposure to pyridine and some of its derivatives may produce headache, nausea, loss of consciousness, nervousness, loss of appetite, sleeplessness and narcosis;  

CHRONIC HEALTH EFFECTS

  There has been concern that this material can cause cancer or mutations, but there is not enough data to make an assessment.  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  Exposure to the material may result in a possible risk of irreversible effects. The material may produce mutagenic effects in man. This concern is raised, generally, on the basis ofappropriate studies with similar materials using mammalian somatic cells in vivo. Such findings are often supported by positive results from in vitro mutagenicity studies.  Data from experimental studies indicate that pyridines represent a potential cause of cancer in man. They have also been shown to cross the placental barrier in rats and cause premature delivery, miscarriages and stillbirths. PAs are passed through breast milk. Pyridine has been implicated in the formation of liver cancers.  Quinoline is a metabolite of this material and in mammals has been shown to cause cancers of the liver and blood vessels. Adequate data in humans is not available.