Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HB FULLER INDASOL MS 1475

NFPA

PRODUCT USE

The use of a quantity of material in an unventilated or confined space may result in
increased exposure and an irritating atmosphere developing.Before starting consider
control of exposure by mechanical ventilation. Adhesive.

SYNONYMS

"MS-1475 adhesive"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

May form explosive peroxides.
HARMFUL - May cause lung damage if swallowed.
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes and respiratory system.
Highly flammable.
Repeated exposure may cause skin dryness and cracking.
Vapors may cause dizziness or suffocation.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Swallowing of the liquid may cause aspiration into the lungs with the risk of chemical pneumonitis; serious consequences may result. (ICSC13733).  Ingestion of tetrahydrofuran may not, in itself, produce internal injury, however, contaminating levels of furan, present in certain grades of commercial product, may produce liver and kidney injury. The intake of alcoholic beverages may enhance the toxic effects of tetrahydrofuran.  

EYE

  This material can cause eye irritation and damage in some persons.  The vapour when concentrated has pronounced eye irritation effects and this gives some warning of high vapour concentrations. If eye irritation occurs seek to reduce exposure with available control measures, or evacuate area.  The material may produce severe irritation to the eye causing pronounced inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.  

SKIN

  Skin contact with the material may be harmful; systemic effects may resultfollowing absorption.  There is some evidence to suggest that the material may cause moderate inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  Skin contact with tetrahydrofuran may produce smarting and reddening of the skin and after prolonged exposures, contact (non-allergic) dermatitis may result due to the degreasing effect of the substance.  The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.  

INHALED

  Inhalation of aerosols (mists, fumes), generated by the material during the course of normal handling, may be harmful.  The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by narcosis, reduced alertness, loss of reflexes, lack of coordination and vertigo.  Ketone vapors irritate the nose, throat and mucous membrane. High concentrations depress the central nervous system, causing headache, vertigo, poor concentration, sleep and failure of the heart and breathing. Some ketones can cause multiple nerve disorders, inducing "pins and needles" and weakness in the limbs.  If exposure to highly concentrated solvent atmosphere is prolonged this may lead to narcosis, unconsciousness, even coma and possible death.  Overexposure to tetrahydrofuran, by inhalation, may result in irritation of the mucous membranes and may produce coughing, chest pains, nausea, dizziness, headache and narcosis. Exposure to high concentrations can affect the central nervous system due to the strong narcotic effect of the material. Concentrations greater than 25000 ppm were reported to produce anaesthesia in animals. Anaesthetic properties are poor as onset is delayed and recovery is slow. Pronounced hypotension and marked respiratory hypernea accompany narcosis. Other symptoms include muscular hypotonia and disappearance of corneal reflexes, followed by coma and death.  

CHRONIC HEALTH EFFECTS

  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that occurs as result of exposure due to high concentrations of irritating substance (often particulate in nature) and is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough and mucus production.  There is some evidence that human exposure to the material may result in developmental toxicity. This evidence is based on animal studies where effects have been observed in the absence of marked maternal toxicity, or at around the same dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects.  Chronic solvent inhalation exposures may result in nervous system impairment and liver and blood changes. [PATTYS].  Long term cyclohexanone exposure may cause liver and kidney changes. Clouding of the eye lens and cataract development may occur. Avoid all exposure in pregnancy, cyclohexanone may cause birth defects.  Repeated exposure to tetrahydrofuran (THF) and its congeners has been associated with cytolytic hepatitis and fatty degeneration of the liver. Inhalation of THF at concentrations greater than 3000 ppm, 8 hours/day for 20 days, produced irritation and evidence for hepatic and renal injury in animals. Male rats inhaling more than 5000 ppm THF for 12 weeks, 4 hours/day showed signs of systemic intoxication, skin and respiratory irritation, liver function disturbance and abnormalities in glucose function. Muscle acetylcholinesterase activity increased in a concentration-dependent manner in male rats that inhaled 200 ppm for 18 weeks, 6 hours/day. Hepatic protein and mixed function oxidase activity also increased. At 2000 ppm, liver function was inhibited. In a 13-week inhalation study, ataxia was reported in rats at 5000 ppm and narcosis in mice at 1800 ppm. Hepatocytomegaly developed in mice of both sexes at 5000 ppm while uterine atrophy and degeneration of the adrenal cortex was found in female mice. A case history suggests that interaction of THF and endoflurane (an anaesthetic) may provoke epileptic seizures following surgery. The parent compound of tetrahydrofuran, furan, is carcinogenic in rats based on an increased incidence of cholangiocarcinoma and hepatocellular neoplasms of the liver and increased incidences of mononuclear cell leukaemia. In male and female mice, furan induced hepatocellular neoplasms and benign pheochromocytomas of the of the adrenal gland. 1,4-Dioxane, another cyclic ether solvent, is carcinogenic in rats and guinea pigs,  following oral administration, inducing malignant tumours of the liver in rats and malignant tumours of the liver of the gall-bladder in guinea pigs. 1,4-Dioxane is a promoter in two stage skin carcinogenic studies in mice. In a two-year inhalation study * there was evidence of carcinogenic activity of THF, in male rats, based on increased incidences of renal tube adenoma or carcinoma (combined) and in female mice based on an increased incidence of hepatocellular neoplasms. There was no evidence of carcinogenic activity in female rats or male mice exposed to 200, 600 and 1800 ppm THF by inhalation. * National Toxicology Program Technical Report Series No. 475.