Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

LEUPEPTIN TRIFLUOROACETATE

NFPA

PRODUCT USE

Peptide. Inhibitor of trypsin, plasmin, papain, and cathepsin. Leupeptins are a class of
modified tripeptide protease inhibitors produced by various species of Actinomycetes. Two
major components, leupeptin Ac- LL and leupeptin Pr- LL, consisting of L- leucyl- L-
leucyl- DL- arginal modified at the amino terminal by acetyl- or propionyl, respectively,
have been isolated. Some sources identify leupeptin as only leupeptin Ac- LL

SYNONYMS

C20-H38-N6-O4, "valeramide, 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-
guanidinobutyl)-4-methyl-, trifluoroacetate", "valeramide, 2-(2-acetamido-4-
methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methyl-, trifluoroacetate", "2-(2-
acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methylvaleramide
fluoroacetate", "2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-
methylvaleramide fluoroacetate", "N-acetyl-L-leucyl-L-leucyl-L-argininal trifluoracetate",
"N-acetyl-L-leucyl-L-leucyl-L-argininal trifluoracetate", "L-leucinamide, ", "L-
leucinamide, ", "N-acetyl-L-leucyl-N-[4-((aminoiminoethyl)amino)-1-formylbutyl)-,
fluoracetate", "N-acetyl-L-leucyl-N-[4-((aminoiminoethyl)amino)-1-formylbutyl)-,
fluoracetate"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Considered an unlikely route of entry in commercial/industrial environments.  The lethal dose of fluoroacetate in humans is 2-10 mg/kg. It is easily absorbed from the digestive system but symptoms of poisoning are delayed for up to a few hours. Their onset is usually insidious, and they include apprehension, auditory hallucinations, tingling sensation of the nose, facial twitching and numbness, and other central nervous system effects. Heart failure and depression of breathing and the vasomotor system can cause death.  

INHALED

  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust.  Ample evidence from experiments exists that there is a suspicionthis material directly reduces fertility.