Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

OKADAIC ACID, SODIUM SALT

NFPA

PRODUCT USE

Salt of a natural product isolated from Prorocentrium spp. Tumour promoter and specific
inhibitor of protein (serine/ threonine) phosphatases 1 and 2A, (phosphatases PP1 and PP2)
an action which it shares with its congener calyculin A. These phosphatases appear to be
involved in neurotransmitter release, control of stimulus- induced gene expression, and in
the phosphorylation of microtubule- related proteins; they also appear to have a have a
role in acetylcholine synthesis and compartmentation.

SYNONYMS

C44-H67-O13.Na, "acanthifolicin, 9, 10-deepithio-9, 10-didehydro-, sodium salt",
"acanthifolicin, 9, 10-deepithio-9, 10-didehydro-, sodium salt", "sodium 9, 10-
deepithio-9, 10-didehydroacanthifolicin", "sodium 9, 10-deepithio-9, 10-
didehydroacanthifolicin"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Irritating to skin.
Limited evidence of a carcinogenic effect.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Considered an unlikely route of entry in commercial/industrial environments.  Ingestion may result in nausea, abdominal irritation, pain and vomiting.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  This material can cause inflammation of the skin oncontact in some persons.  Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions.  Irritating to skin.  Toxic effects may result from skin absorption.  

INHALED

  Inhalation may produce serious health damage*.  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of the material, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  There has been concern that this material can cause cancer or mutations, but there is not enough data to make an assessment.  

  Limited evidence of a carcinogenic effect.  Limited evidence of a carcinogenic effect.  Limited evidence suggest tha okadaic acid is a tumour promoter in  laboratory animals.  Inhibition of serine-threonine phosphatases PP1 and PP2a causes hyperphosphorylation of regulatory cellular proteins involved in the expression of growth regulatory genes. This may have a tumour-promoting effect on previously dormant neoplastic cells.