Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

NALTREXONE HYDROCHLORIDE

STATEMENT OF HAZARDOUS NATURE

Not considered a hazardous substance according to OSHA 29 CFR 1910.1200.

NFPA

PRODUCT USE

An intermediate chemical used in the preparation of pharmaceutical preparations for the
treatment of drug dependence.

SYNONYMS

"N-cyclopropylmethyl-14-hydroxydihydromorphinone hydrochloride", "N-cyclopropylmethyl-14-
hydroxydihydromorphinone hydrochloride", "17-cyclopropylmethyl-4, 5-epoxy-3, 14-
dihydroxymorphinane-6-one, hydrochloride", "17-cyclopropylmethyl-4, 5-epoxy-3, 14-
dihydroxymorphinane-6-one, hydrochloride", "Opioid antagonist", "opiate blocker",
"pharmaceutical intermediate"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

None

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are usually by inhalation of dust from the dried material and skin contact.  The free base, Naltrexone, is well absorbed from the intestinal tract and  has long duration of action. Non- addictive congener of naloxone.  High doses may prove hepatotoxic. Symptoms of chronic poisoning may not be  readily apparent.