Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

O-TOLYL BIGUANIDE

NFPA

PRODUCT USE

Rubber vulcanising agent. Intermediate. Reagent. Used according to manufacturer' s
directions.

SYNONYMS

C9-H13-N5, "biguanide, 1-o-tolyl-", "biguanide, 1-o-tolyl-", "N-(2-
methylphenyl)imidodicarbonimidic diamide", "N-(2-methylphenyl)imidodicarbonimidic
diamide", "tolyl diguanide", o-tolylbiguanide, o-tolylbiguanide, ortho-tolylbiguanide,
"Vulkacit 1000"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful if swallowed.
Irritating to eyes.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Biguanides, drugs used in treating type II diabetes mellitus, have been associated with the metabolic condition lactic acidosis which is highly dangerous and often fatal especially if taken with alcohol. Overexposure may cause fixed dilated pupils and lack of eye reflexes, nausea, vomiting, diarrhea, loss of appetite and weight, abdominal discomfort, blood in vomit, agitation, confusion, lethargy, spasticity, and coma. Increased heart rate, decreased blood pressure and heart attack may occur. The skin is dry and dehydration is common. Biguanides do not elicit a therapeutic response in the non-  diabetic.  

EYE

  This material can cause eye irritation and damage in some persons.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  Inhalation of dust may aggravate a pre-existing respiratory condition such as asthma, bronchitis, emphysema.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are by accidental skin and eye contact andinhalation of generated dusts.  Guanidine hydrochloride causes decrease in bone marrow activity usually shown as gastrointestinal disturbance and "pins and needles" in the lips, face and extremities. Irritability, tremor, inco-ordination and seizures can occur, rarely, there is low blood pressure, skin reactions, low blood glucose and increased levels of creatinine. Asians may be more susceptible. Chronic exposure may cause kidney damage.