Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

KHELLIN

NFPA

PRODUCT USE

Vasodilator which relaxes smooth muscle and has been employed in the treatment of angina
pectoris and in the treatment of asthma. Now believed to have no specific physiological
efficacy and its use in angina treatment has been largely discontinued. Formerly extracted
from seeds of Ammi visnaga Lam., Umbelliferae (toothpick ammi; chellah; khella). Dye

SYNONYMS

C14-H12-O5, "5, 8-dimethoxy-2-methyl-4', 5'-furano-6, 7-chromone", "5, 8-dimethoxy-2-
methyl-4', 5'-furano-6, 7-chromone", "5, 8-dimethoxy-2-methyl-6, 7-furanochromone", "5, 8-
dimethoxy-2-methyl-6, 7-furanochromone", "4, 9-dimethoxy-7-methyl-5H-furo(3, 2-
g)(1)benzopyran-5-one", "4, 9-dimethoxy-7-methyl-5H-furo(3, 2-g)(1)benzopyran-5-one", "5,
8-dimethoxy-2-methyl-4', 5'-furo-6, 7-chromone", "5, 8-dimethoxy-2-methyl-4', 5'-furo-6,
7-chromone", "4, 9-dimethoxy-7-methyl-5-oxo-1, 2-dioxabenz-(f)indene", "4, 9-dimethoxy-7-
methyl-5-oxo-1, 2-dioxabenz-(f)indene", "4, 9-dimethoxy-7-methyl-5-oxofuro(3, 2-
g)(1)benzopyran", "4, 9-dimethoxy-7-methyl-5-oxofuro(3, 2-g)(1)benzopyran", "4, 9-
dimethoxy-7-methyl-5-oxofuro(3, 2-g)-1, 2-chromene", "4, 9-dimethoxy-7-methyl-5-oxofuro(3,
2-g)-1, 2-chromene", Amicardine, Amiptan, Amnicardine, Amni-Khellin, Ammispasmin,
Ammipuran, Ammivin, Ammivisnagen, Benecardin, Bi-Kellina, Cardio-Khellin, Chellin,
Chorafurone, Coronin, Deltoside, Eskel, Euphorin, Gynokhellan, Intercellin, Interkellin,
Interkhellin, IT-033, Kelamin, Kelicor, Kelicorin, Kelincor, Kellin, Keloid, Kelorin,
Khelangin, Khelfren, Khelisem, Khell, Khellamine, Khellanals, Khellinorm, Khelloyd,
Lyamine, Mefurina, Methafrone, Norkel, Rykellin, Simeskellina, Vasokellina, Visammimix,
Visammin, Viscardan, Viscardin, Vismagen, Visnagalin, Visnagen

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Toxic if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual.  Accidental ingestion of the material may be damaging to the health of the individual.  When given by mouth or by injection, in therapeutic doses, vasodilators may produce transient flushing of the face, a sensation of heat, a pounding in the head, peripheral oedema, headache, hypotension, palpitations, dizziness and fatigue. Most reactions are dose dependent and transient. High doses may cause flushing and dryness of the skin, skin lesions, abdominal cramps, diarrhoea, nausea, vomiting, malaise, anorexia, activation of peptic ulcer, jaundice and impairment of liver function, decrease in glucose tolerance, mild diabetes and hyperuricaemia. Most of these effects subside with withdrawal of the drug.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. The material may produce foreign body irritation in certain individuals.  

SKIN

  The material is not thought to be a skin irritant (as classified using animal models). Abrasive damage however, may result from prolonged exposures. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.  Open cuts, abraded or irritated skin should not be exposed to this material.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  

INHALED

  Inhalation may produce health damage*.  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of dusts, or fume, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  Inhalation of dusts, generated by the material during the course of normal handling, may be damaging to the health of the individual.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Long-term exposure to the product is not thought to produce chronic effects adverse to the health (as classified using animal models); nevertheless exposure by all routes should be minimized as a matter of course.  Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray.