Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

LAMOTRIGINE

NFPA

PRODUCT USE

Antiepileptic drug for treatment of partial seizures. In vitro and in vivo studies
indicate that lamotrigine can inhibit voltage gated sodium channels and reduce the release
of glutamate, an excitory amino- acid implicated in the pathophysiology of epilepsy.

SYNONYMS

C9-H7-Cl2-N5, "1, 2, 4-triazine-3, 5-diamine, 6-(2, 3-dichlorophenyl)-", "1, 2, 4-
triazine-3, 5-diamine, 6-(2, 3-dichlorophenyl)-", BW-430C, "3, 5-diamino-6-(2, 3-
dichlorophenyl)-1, 2, 4-triazine-3, 5-diamine", "3, 5-diamino-6-(2, 3-dichlorophenyl)-1,
2, 4-triazine-3, 5-diamine", Lamictal, LTG, antiepileptic

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Considered an unlikely route of entry in commercial/industrial environments.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust.  Lamotrigine is a weak inhibitor of dihydrofolate reductase and thus may  interfere with folate metabolism in long-term therapies.  The results of mutagenicity tests revealed that the substance did not  present genetic risk to man. Nor did the substance exhibit carcinogenicity  in rat or mice trials.