Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

VERNOLATE

NFPA

PRODUCT USE

Selective systemic herbicide absorbed by roots for the control of germinating broad-
leaved and grass weeds. Inhibits growth in the meristematic region of the leaves.

SYNONYMS

C10-H21-N-O-S, C10-H21-N-O-S, (CH3CH2CH2)2NC(=O)SCH2CH2CH3, "carbamothioic acid,
dipropyl-, S-propyl ester", "carbamothioic acid, dipropyl-, S-propyl ester",
"dipropylcarbamothioic acid S-propyl ester", "dipropylcarbamothioic acid S-propyl ester",
"carbamic acid, dipropylthio-, S-propyl ester", "carbamic acid, dipropylthio-, S-
propyl ester", "dipropylthiocarbamic acid S-propyl ester", "dipropylthiocarbamic acid S-
propyl ester", "S-propyl dipropylcarbamothioate", "S-propyl dipropylcarbamothioate", "S-
propyl dipropyl(thiocarbamate)", "S-propyl dipropyl(thiocarbamate)", "S-propyl
dipropylthiocarbamate", "S-propyl dipropylthiocarbamate", "propyl dipropylthiolcarbamate",
Perbulate, PPTC, R-1607, R-1607, Vanalate, Vernam, "pesticide/ herbicide"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful if swallowed.
Toxic to aquatic organisms, may cause long- term adverse effects in the aquatic
environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Considered an unlikely route of entry in commercial/industrial environments.  The acute toxicity of thiocarbamates is generally low, because of their rapid metabolism. Exposure to high doses may produce signs such as loss of appetite, squinting, excessive production of saliva, watery eyes, hairs standing on end, labored breathing, reduced body temperature, incoordination, depression and rapid muscle twitching.  The thioureas, which are antithyroid drugs, can cause headache,anxiety, fever, rash and stomach upset.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Open cuts, abraded or irritated skin should not be exposed to this material.  The material may accentuate any pre-existing skin condition.  Skin sensitivity to thiourea derivatives has been demonstrated in several studies. Allergic contact dermatitis and photocontact dermatitis have been described. A Russian study published in 1970 reported that workers handling thiourea products showed ready penetration through the skin which lead to clinical evidence of destructive changes in the thyroid gland.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  

CHRONIC HEALTH EFFECTS

  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  

  Principal routes of exposure are by accidental skin and eye contact and by inhalation of vapors especially at higher temperatures.  Male rats receiving oral doses of 80 mg/kg/day for 51 weeks showed  significantly increased mortality due to haemorrhage. Dose rates of  20 mg/kg/day for 51 weeks produced an increase in blood clotting times.  In a 24 month study in mice, no oncogenic potential was revealed at doses  up to 100 mg/kg/day