Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

RANATENSIN

STATEMENT OF HAZARDOUS NATURE

Not considered a hazardous substance according to OSHA 29 CFR 1910.1200.

NFPA

PRODUCT USE

Peptide related to a fragment of bombesin, a tetradecapeptide with stimulatory effects on
gastric and pancreatic secretions in mammals. Other actions of bombesin include
hypertensive reactions, antidiuresis, and hyperglycaemic activity. Bombesin lowers core
temperature in rats and acts as a mitogen through the inosital lipid pathway. Bombesin is
found in skins of European amphibians of the family Discoglossidae, principally Bombina
bombina and Bombina variegata variegata; high intracellular levels found in human small-
cell lung carcinoma; a bombesin- like immunoreactive peptide is found in both mammalian
brain and gut.

SYNONYMS

C61-H84-N16-O13-S, polypeptide, peptide

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

None

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Considered an unlikely route of entry in commercial/industrial environments.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust.  No human exposure data available. For this reason health effects described are based on experience with chemically related materials.  As with any chemical product, contact with unprotected bare skin; inhalation of vapor, mist or dust in work place atmosphere; or ingestion in any form, should be avoided by observing good occupational work practice.