Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

PAMIDRONIC ACID

NFPA

PRODUCT USE

Calcium metabolism regulator.

SYNONYMS

C3-H11-N-O7-P2, C3-H11-N-O7-P2, H2NCH2CH2C(HPO4)2OH, "ADP acid", AHPrBP, "3-amino-1-
hydroxypropylidene-1, 1-bisphosphonic acid", "3-amino-1-hydroxypropylidene-1, 1-
bisphosphonic acid", "(3-amino-1-hydroxypropylidene)diphosphonic acid", "(3-amino-1-
hydroxypropylidene)diphosphonic acid", "aminohydroxypropylidene diphosphonic acid",
bisphosphonate, "calcium metabolism regulator"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful if swallowed.
Irritating to respiratory system.
May cause long- term adverse effects in the aquatic environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Considered an unlikely route of entry in commercial/industrial environments.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  The material may be irritating to the eye, with prolonged contact causing inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.  

INHALED

  If inhaled, this material can irritate the throat andlungs of some persons.  Although inhalation is not thought to produce harmful effects, the material may still produce health damage, especially where pre-existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally confined to doses producing mortality (death) rather than those producing morbidity (disease, ill-  health).  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  The material may produce respiratory tract irritation, and result in damage to the lung including reduced lung function.  Respiratory sensitization may result in allergic/asthma like responses; from coughing and minor breathing difficulties to bronchitis with wheezing, gasping.  

CHRONIC HEALTH EFFECTS

  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  

  Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust.  Prolonged use may produce hypocalcaemia, a susceptibility to fracture  bones, anaemia, kidney damage, and gastrointestinal irritation with  ulceration. Although the material has not been subjected to controlled  pregnancy studies in humans, animal experiments have produced birth  abnormalities.  Exposure to small quantities may induce hypersensitivity reactions characterized by acute bronchospasm, hives (urticaria), deep dermal wheals (angioneurotic edema), running nose (rhinitis) and blurred vision . Anaphylactic shock and skin rash (non-thrombocytopenic purpura) may occur. An individual may be predisposed to such anti-body mediated reaction if other chemical agents have caused prior sensitization (cross-sensitivity).