Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

ZD0473

NFPA

PRODUCT USE

An anti- neoplastic agent designed to avoid platinum resistance exhibited by other
platinum- based drugs. Drug design was aimed at limiting the ability of platinum to enter
cells, allow the efficient repair of dmage to DNA caused by the drug, and to avoid
production of excessive amounts of glutathione a compound that deactivates platinum drugs.

SYNONYMS

"ZDO473/ ZD 0473/ ZD O473", "platinum antineoplastic/ cytotoxic"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Toxic if swallowed.
Irritating to eyes.
Limited evidence of a carcinogenic effect.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual.  Toxic if swallowed.  

EYE

  This material can cause eye irritation and damage in some persons.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Toxic effects may result from skin absorption.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  The killing action of antineoplastic drugs used for cancer chemotherapy is not selective for cancerous cells alone but affect all dividing cells. Acute side effects include loss of appetite, nausea and vomiting, allergic reaction (skin rash, itch, redness, low blood pressure, unwellness and anaphylactic shock) and local irritation. Gout and renal failure can occur.  

CHRONIC HEALTH EFFECTS

  There has been concern that this material can cause cancer or mutations, but there is not enough data to make an assessment.  

  Harmful: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed.  Harmful: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed.  irreversible effects  Studies in animals have shown that repeated doses produce adverse effects  in many tissues and organs. In vitro and in vivo studies indicate  genotoxic effects.  A study in animals has shown that repeated doses produce embyro/  foetotoxic effects in the presence of maternal toxicity (including  embryolethality).  Platinum salt complexes can cause immediate hypersensitivity reactions either by contact or inhalation known as "platinosis". Symptoms include asthma, runny nose, inflammation of skin, eczema and hives, cough, inflammation of the nose and throat, difficulty breathing, itching, and dilation of the blood vessels of the conjunctiva.  Anti-cancer drugs used for chemotherapy can depress the bone marrow with reduction in the number of white blood cells and platelets and bleeding. Susceptibility to infections and bleeding is increased, which can be life- threatening. Digestive system effects may include inflammation of the mouth cavity, mouth ulcers, esophagus inflammation, abdominal pain and bleeds, diarrhea, bowel ulcers and perforation. Reversible hair loss can result and wound healing may be delayed. Long-term effects on the gonads may cause periods to stop and inhibit sperm production. Most anti-cancer drugs can potentially cause mutations and birth defects, and coupled with the effects of the suppression of the immune system, may also cause cancer.