Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

VERAPAMIL RELATED COMPOUD B

NFPA

PRODUCT USE

The congener, verapamil is used in the control of supraventricular tachyarrhythmias and in
the management angina pectoris (classical and variant) and hypertension. A calcium-
channel blocker classified as a class IV anti- arrhythmic agent.

SYNONYMS

C26-H36-N2-O4.HCl, "benzeneacetonitrile, ", "alpha-[2-((2-(3, 4-
dimethoxyphenyl)ethyl)methylamino)ethyl]-3, 4-dimethoxy-alpha-(1-methylethyl)-, ", "alpha-
[2-((2-(3, 4-dimethoxyphenyl)ethyl)methylamino)ethyl]-3, 4-dimethoxy-alpha-(1-
methylethyl)-, ", monohydrochloride, "calcium channel blocker anti-arrhythmic"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Toxic if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual.  Accidental ingestion of the material may be damaging to the health of the individual.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. The material may produce foreign body irritation in certain individuals.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  

INHALED

  Inhalation of dusts, generated by the material during the course of normal handling, may be damaging to the health of the individual.  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of dusts, or fume, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  

CHRONIC HEALTH EFFECTS

  Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray.  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.