Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

URETHANE BISOXAZOLIDINE

NFPA

PRODUCT USE

Oxazolidine latent hardener

SYNONYMS

C24-H46-N4-O6, "carbamic acid, 1, 6-hexanediylbis-, ", "carbamic acid, 1, 6-
hexanediylbis-, ", "bis[2-(2-(1-methylethyl)-3-oxazolidinyl)ethyl] ester", "bis[2-(2-(1-
methylethyl)-3-oxazolidinyl)ethyl] ester", "bis[2-[2-(1-methylethyl)-3-
oxazolidinyl]ethyl] hexan-1, 2-diylbiscarbamate", "bis[2-[2-(1-methylethyl)-3-
oxazolidinyl]ethyl] hexan-1, 2-diylbiscarbamate", "Incozol 4", "Hardener O2"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

In use, may form flammable/ explosive vapor- air mixture.
HARMFUL - May cause lung damage if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  The material has NOT been classified as "harmful by ingestion". This is because of the lack of corroborating animal or human evidence. The material may still be damaging to the health of the individual, following ingestion, especially where pre-existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, unintentional ingestion is not thought to be cause for concern.  

EYE

  There is some evidence to suggest that this material can causeeye irritation and damage in some persons.  Because of their alkaline nature eye contact with oxazolidines may produces moderate to severe irritation depending on the duration of contact.  

SKIN

  Irritation and skin reactions are possible with sensitive skin.  There is some evidence to suggest that this material can cause inflammation of the skin on contact in some persons.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions.  Oxazolidines generally do not produce systemic harmful following skin contact but, because of their alkaline nature, may produce moderate to severe irritation. Dermal reactions may include necrosis, sloughing and scab formation.  

INHALED

  There is some evidence to suggest that the material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by narcosis, reduced alertness, loss of reflexes, lack of coordination and vertigo.  The material has NOT been classified as "harmful by inhalation". This is because of the lack of corroborating animal or human evidence. In the absence of such evidence, care should nevertheless be taken to ensure exposure is kept to a minimum and that suitable control measures be used, in an occupational setting to control vapors, fumes and aerosols.  Exposure to aldehydes causes neurological symptoms such as headache, drowsiness, dizziness, seizures, depression and coma. Cardiovascular involvement may result in increased heart rate, collapse and low blood pressure; respiratory effects include throat spasms, irritation, difficulty swallowing, pulmonary edema and an asthma-like condition. Gastrointestinal signs include nausea, blood in vomit, diarrhea, ulcers and abdominal pain. Massive exposures may damage the kidney and liver.  

CHRONIC HEALTH EFFECTS

  There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment.  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population.  Although oxazolidines are able to cross-link with dermal proteins, there is no indication,  at present, that they are dermal sensitisers.  Oral teratology studies indicate that foetal toxicity occurs occurs at maternally toxic doses but that birth defects are not a feature of exposure.  Oxazolidines are generally not mutagenic in a battery of tests designed to investigate this effect.  Because they occur as secondary and tertiary amines, the concomitant use of nitrates may result in the production of potentially carcinogenic N-nitrosoamines. There is no evidence available to suggest that oxazolidines constitute a class of carcinogenic substance.  Alkyl-carbamates can promote the growth of, but do not directly cause, livercancer.