Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

QIAGEN BUFFER ML

NFPA

PRODUCT USE

Buffer solution. Used according to manufacturer' s directions.

SYNONYMS

"laboratory reagent", "buffer solution"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Contact with acids liberates very toxic gas.
Causes burns.
Risk of serious damage to eyes.
Harmful by inhalation, in contact with skin and if swallowed.
Harmful to aquatic organisms, may cause long- term adverse effects in the
aquatic environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Considered an unlikely route of entry in commercial/industrial environments.  The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion.  

EYE

  The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating.  If applied to the eyes, this material causes severe eye damage.  

SKIN

  Skin contact with the material may be harmful; systemic effects may resultfollowing absorption.  The material can produce chemical burns following direct contactwith the skin.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  Toxic effects may result from skin absorption.  The material may accentuate any pre-existing skin condition.  

INHALED

  Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be harmful.  The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are by accidental skin and eye contact and by inhalation of vapors especially at higher temperatures.  Repeated or prolonged exposure to corrosives may result in the erosion of teeth, inflammatory and ulcerative changes in the mouth and necrosis (rarely) of the jaw. Bronchial irritation, with cough, and frequent attacks of bronchial pneumonia may ensue. Gastrointestinal disturbances may also occur. Chronic exposures may result in dermatitis and/or conjunctivitis.  Subacute or chronic poisonings by thiocyanate produce profuse discharge from the nostrils,  skin rashes, weakness, fatigue, spinning sensation, nausea, vomiting, diarrhea, confusion,  disorientation and forgetfulness.  Guanidine hydrochloride causes decrease in bone marrow activity usually shown as gastrointestinal disturbance and "pins and needles" in the lips, face and extremities. Irritability, tremor, inco-ordination and seizures can occur, rarely, there is low blood pressure, skin reactions, low blood glucose and increased levels of creatinine. Asians may be more susceptible. Chronic exposure may cause kidney damage.