VIS 1C-LOSUNG
Flammability | 3 | |
Toxicity | 3 | |
Body Contact | 3 | |
Reactivity | 0 | |
Chronic | 2 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Unknown.
Irritating to skin.
Toxic by inhalation, in contact with skin and if swallowed.
Toxic: danger of very serious irreversible effects through inhalation, in
contact with skin and if swallowed.
Highly flammable.
Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual. Methanol may produce a burning or painful sensation in the mouth, throat, chest, and stomach. This may be accompanied by nausea, vomiting, headache, dizziness, shortness of breath, weakness, fatigue, leg cramps, restlessness, confusion, drunken behavior, visual disturbance, drowsiness, coma and death. These symptoms may not occur until several hours after exposure. Visual impairment produces blurring, double vision, color distortion, reduced visual field, and blindness. In higher doses, the liver, kidney, heart and muscle can all be damaged. 10mL can cause blindness, and 60-200mL will cause death in adults.
There is some evidence to suggest that this material can causeeye irritation and damage in some persons. The material may produce moderate eye irritation leading to inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.
Skin contact with the material may produce toxic effects; systemic effectsmay result following absorption. This material can cause inflammation of the skin oncontact in some persons. Toxic effects may result from skin absorption. The material may cause severe skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin. Repeated exposures may produce severe ulceration.
The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of the material, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress. Inhalation hazard is increased at higher temperatures. Inhalation exposure may cause susceptible individuals to show change in heart beat rhythm i.e. cardiac arrhythmia. Exposures must be terminated. Acute intoxication by halogenated aliphatic hydrocarbons appears to take place over two stages. Signs of a reversible narcosis are evident in the first stage and in the second stage signs of injury to organs may become evident, a single organ alone is (almost) never involved. Depression of the central nervous system is the most outstanding effect of most halogenated aliphatic hydrocarbons. Inebriation and excitation, passing into narcosis, is a typical reaction. In severe acute exposures there is always a danger of death from respiratory failure or cardiac arrest due to a tendency to make the heart more susceptible to catecholamines (adrenalin).
Principal routes of exposure are usually by inhalation of vapor and skin contact/absorption. Dichloromethane is stored in body fat and metabolized to carbon monoxide, which reduces the oxygen carrying capacity of blood. Minor but regular methanol exposures may effect the central nervous system, optic nerves and retinae. Symptoms may be delayed, with headache, fatigue, nausea, blurring of vision and double vision. Continued or severe exposures may cause damage to optic nerves, which may become severe with permanent visual impairment even blindness resulting. WARNING: Methanol is only slowly eliminated from the body and should be regarded as a cumulative poison which cannot be made non-harmful [CCINFO]. Long-term exposure to methanol vapor, at concentrations exceeding 3000 ppm, may produce cumulative effects characterized by gastrointestinal disturbances (nausea, vomiting), headache, ringing in the ears, insomnia, trembling, unsteady gait, vertigo, conjunctivitis and clouded or double vision. Liver and/or kidney injury may also result. Some individuals show severe eye damage following prolonged exposure to 800 ppm of the vapor. As with any chemical product, contact with unprotected bare skin; inhalation of vapor, mist or dust in work place atmosphere; or ingestion in any form, should be avoided by observing good occupational work practice.