Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

Q-DRENCH MULTI COMBINATION DRENCH FOR SHEEP

NFPA

PRODUCT USE

Anthelmintic for use in sheep.

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful by inhalation and if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Immunostimulants, especially when given for prolonged periods produce a range of adverse and diverse effects. In common with other immunomodulators, therapeutic use of this class of drug may exacerbate the primary underlaying disease. Hypersensitivity reactions such as fever, an influenza-like syndrome, arthralgia, muscle pain, skin rashes and cutaneous vasculitis, may occur. Central nervous system effects such as fatigue, headache, confusion, insomnia, dizziness, excitation and convulsions have been reported. Other side-  effects include haematological abnormalities such as agranulocytosis, leukopenia and thrombocytopenia and gastrointestinal disturbances, such as abnormal taste in the mouth.  Benzimidazole carbamate anthelmintics, when administered in therapeutic doses, have produced allergic reaction (which may be associated with destruction of parasites), raised liver enzyme values,and may be associated with leukopenia and alopecia. Extremely large oral doses may produce intestinal cramps, anorexia, lethargy, pulmonary haemorrhage,  oedema, hepatic and epicardial haemorrhage, and nausea, vomiting and diarrhoea. Other symptoms include dizziness, giddiness, tinnitus, insomnia, anxiety, confusion, convulsions, hallucinations and headache. Overdose may produce gastrointestinal symptoms, visual disturbance and psychic alterations. Absorption is generally limited.  Animal studies suggest that this family of drugs may also be teratogenic.  

EYE

  Although the liquid is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The liquid may be miscible with fats or oils and may degrease the skin, producing a skin reaction described as non-allergic contact dermatitis. The material is unlikely to produce an irritant dermatitis as described in EC Directives .  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  

INHALED

  Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be harmful.  

CHRONIC HEALTH EFFECTS

  Iodine and iodides, may give rise to local allergic reactions such as hives, rupture of skin blood vessels, pain in joints or diseases of the lymph nodes.  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population.  There is some evidence that human exposure to the material may result in developmental toxicity. This evidence is based on animal studies where effects have been observed in the absence of marked maternal toxicity, or at around the same dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects.  Exposure to the material for prolonged periods may cause physical defects in the developing embryo (teratogenesis).  Iodine and iodides cause goiter and diminished as well as increased activity of the thyroid gland. A toxic syndrome resulting from chronic iodide overdose and from repeated administration of small amounts of iodine is characterized by excessive saliva production,  head cold, sneezing, conjunctivitis, headache, fever, laryngitis, inflammation of the bronchi and mouth cavity, inflamed parotid gland, and various skin rashes. Swelling and inflammation of the throat, irritated and swollen eyes and lung swelling may also occur. Swelling of the glottis, necessitating a tracheotomy has been reported. Use of iodides in frequency can cause fetal death, severe goiter, hypothyroidism and the cretinoid appearance of the newborn.