Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

WATERS CORPORATION LOW UV PIC B REAGENTS

NFPA

PRODUCT USE

Reagent.

SYNONYMS

reagent

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Toxic by inhalation, in contact with skin and if swallowed.
Toxic: danger of very serious irreversible effects through inhalation, in
contact with skin and if swallowed.
Highly flammable.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual.  There is some evidence to suggest that this material can cause, if swallowed once, very serious, irreversible damage of organs.  Methanol may produce a burning or painful sensation in the mouth, throat, chest, and stomach. This may be accompanied by nausea, vomiting, headache, dizziness, shortness of breath, weakness, fatigue, leg cramps, restlessness, confusion, drunken behavior, visual disturbance, drowsiness, coma and death. These symptoms may not occur until several hours after exposure. Visual impairment produces blurring, double vision, color distortion, reduced visual field, and blindness. In higher doses, the liver, kidney, heart and muscle can all be damaged. 10mL can cause blindness, and 60-200mL will cause death in adults.  

EYE

  There is some evidence to suggest that this material can causeeye irritation and damage in some persons.  This material can cause eye irritation and damage in some persons.  The material may produce moderate eye irritation leading to inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.  

SKIN

  Skin contact with the material may produce toxic effects; systemic effectsmay result following absorption.  This material can cause inflammation of the skin oncontact in some persons.  There is strong evidence to suggest that this material, on a single contact with skin, can cause serious, irreversible damage of organs.  The material may accentuate any pre-existing dermatitis condition.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.  

INHALED

  There is some evidence to suggest that this material, if inhaled, can irritate the throat and lungs of some persons.  Not normally a hazard due to non-volatile nature of product.  Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may produce toxic effects.  The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  

CHRONIC HEALTH EFFECTS

  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that occurs as result of exposure due to high concentrations of irritating substance (often particulate in nature) and is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough and mucus production.  Long-term exposure to methanol vapor, at concentrations exceeding 3000 ppm, may produce cumulative effects characterized by gastrointestinal disturbances (nausea, vomiting), headache, ringing in the ears, insomnia, trembling, unsteady gait, vertigo, conjunctivitis and clouded or double vision. Liver and/or kidney injury may also result. Some individuals show severe eye damage following prolonged exposure to 800 ppm of the vapor.