Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

N-BUTANOL-D10

NFPA

PRODUCT USE

Reagent.

SYNONYMS

C4-D10-O, 1-butanol-D10, 1-butanol-D10, "1-butan-1, 1, 2, 2, 3, 3, 4, 4, 4-D9-ol-D", "1-
butan-1, 1, 2, 2, 3, 3, 4, 4, 4-D9-ol-D", "butyl-D9 alcohol-D]", decadeutero-1-butanol,
decadeutero-1-butanol, perdeutero-1-butanol, perdeutero-1-butanol, "RCRA U031"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

HARMFUL - May cause lung damage if swallowed.
Flammable.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Ingestion may result in nausea, pain, vomiting. Vomit entering the lungs by aspiration may cause potentially lethal chemical pneumonitis.  Considered an unlikely route of entry in commercial/industrial environments.  Overexposure to non-ring alcohols causes nervous system symptoms. These include headache, muscle weakness and inco-ordination, giddiness, confusion, delirium and coma. Digestive symptoms may include nausea, vomiting and diarrhea. Aspiration is much more dangerous than ingestion because lung damage can occur and the substance is absorbed into the body. Alcohols with ring structures and secondary and tertiary alcohols cause more severe symptoms, as do heavier alcohols.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.  The material is not thought to be a skin irritant (as classified using animal models). Temporary discomfort, however, may result from prolonged dermal exposures. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Toxic effects may result from skin absorption.  Exposure limits with "skin" notation indicate that vapor and liquid may be absorbed through intact skin. Absorption by skin may readily exceed vapor inhalation exposure. Symptoms for skin absorption are the same as for inhalation. Contact with eyes and mucous membranes may also contribute to overall exposure and may also invalidate the exposure standard.  Toxic effects may result from skin absorption.  

INHALED

  Inhalation may produce health damage*.  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of the material, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  Inhalation hazard is increased at higher temperatures.  If exposure to highly concentrated solvent atmosphere is prolonged this may lead to narcosis, unconsciousness, even coma and possible death.  Central nervous system (CNS) depression may include general discomfort, symptoms of giddiness, headache, dizziness, nausea, anaesthetic effects, slowed reaction time, slurred speech and may progress to unconsciousness. Serious poisonings may result in respiratory depression and may be fatal.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are usually by skin contact/absorption and inhalation of vapor.  Serious systemic effects from exposure to n-butanol in the form of  auditory and vestibular nerve damage have been reported amongst workers in  France and Mexico. Audiologic impairment was produced in workers exposed  to 80 ppm n-butanol with unprotected noise exposure. Workers exposed over  a 15 year period (1929-1944) exhibited severe vertigo and vertiges gravis.  Workers exposed from 3-11 years without personal protective equipment from  noise experienced greater hearing loss (hypoacusia) in direct relation to  exposure time when compared to a control group exposed to industrial noise  of 90-100 dB but with n-butanol exposure. Average hearing loss was not  large but the workers had central frequencies of 21.98 dB (11.59 dB  minimum and 32.30 dB maximum) with a mean widening of the break between  3000 and 4000 Hz of 42.22 dB. There was a tendency of the averages to  decrease as the frequencies moved away from the central zone. Affected  workers were aged from 20-39 years. [ACGIH Documentation of TLVs]