Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

LITHIUM AMIDE

NFPA

PRODUCT USE

In Claisen condensations, alkylation of nitriles and ketones, synthesis of acetylinic
carbinols and ethynyl compounds. Synthesis of pharmaceuticals including anti- histamines.

SYNONYMS

H2-Li-N, LiNH2, lithamide

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Contact with water liberates extremely flammable gases.
Flammable.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Lithium, in large doses, can cause dizziness and weakness. If a low salt diet is in place,  kidney damage can result. There may be dehydration, weight loss, skin effects and thyroid disturbances. Central nervous system effects include slurred speech, blurred vision, numbness, inco-ordination and convulsions. Repeated exposure can cause diarrhea, vomiting,  tremor, muscle jerks and very brisk reflexes.  Large doses of ammonia or injected ammonium salts may produce diarrhea and may be sufficiently absorbed to produce increased production of urine and systemic poisoning. Symptoms include weakening of facial muscle, tremor, anxiety, reduced muscle and limb control.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Solution of material in moisture on the skin, or perspiration, may markedly increase skin corrosion and accelerate tissue destruction.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are by accidental skin and eye contact andinhalation of generated dusts.  Lithium compounds can affect the nervous system and muscle. This can cause tremor, inco-  ordination, spastic jerks and very brisk reflexes. They may cause birth defects and should not be used when pregnancy is suspected. They are effective in treating manic episodes of bipolar disorder. Restricting sodium in the diet increases the risks of taking lithium.  As with any chemical product, contact with unprotected bare skin; inhalation of vapor, mist or dust in work place atmosphere; or ingestion in any form, should be avoided by observing good occupational work practice.