LEUKOTRIENE E5
Flammability | 1 | |
Toxicity | 1 | |
Body Contact | 0 | |
Reactivity | 0 | |
Chronic | 2 | |
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 |
Leukotrienes comprise a family of endogenous metabolites of certain fatty acids and are
related to the prostaglandins and thromboxanes. They are generally derived from leukocytes
and possess a conjugated triene structure (hence the name). Leukotrienes derived from
arachidonic acid have the subscript 4, those derived from eicosotrienoic acid possess the
subscript 3 and those derived from eicosapentanoic acid possess the subscript 5.
C25-H38-N2-O6-S, "((5S, 6R)-5-hydroxy-6-(S-cysteinyl)-(7E, 9E, 11Z, 14Z, 17Z)-
eicosapentaenoicacid", "((5S, 6R)-5-hydroxy-6-(S-cysteinyl)-(7E, 9E, 11Z, 14Z, 17Z)-
eicosapentaenoicacid", "prostaglandin/ thromboxane/ leukotriene"
Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern. Considered an unlikely route of entry in commercial/industrial environments.
Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust. Some leukotrienes can severely narrow the airways and also mediate the inflammatory response, causing a wide range of effects such as decreased blood flow to the heart and low blood pressure. Allergies can occur, with irregular heart beats. There may also be dizziness, flushing and nausea.