Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

KATACALCIN [TYR]

NFPA

PRODUCT USE

Calcitonin precursor protein. Calcitonin is a calcium regulating hormone secreted from
mammalian thyroid parafollicular cells and in non- mammalian species from the
ultimobranchial gland. It produces hypocalcaemic and hypophosphataemic action (lowers
blood calcium and phosphate levels) due to the inhibition of bone resorption and decreases
urinary calcium ion concentrations. Overall action opposes the bone and renal effects of
parathyroid hormone. Calcitonin also abolishes the osteolytic (bone degrading) effects of
toxic doses of vitamin A and D. High biological activity. Calcitonins are used in the
treatment of selected patients with diseases characterised by bone resorption and
reformation such as Paget' s disease (osteitis deformans) and for hypercalcaemia produced
by vitamin D intoxication, neoplastic disease, thyrotoxicosis and hyperparathyroidism.
Normally given by intravenous or subcutaneous injection.

SYNONYMS

C97-H154-N34-O36-S2, "bioactive peptide", Asp-Met-Ser-Ser-Asp-Leu-Glu-Arg-Asp-His-Arg-Pro-
His-Val-Ser-Met-Pro-Gln-Asn-Ala-Asn, "human calcitonin precursor peptide", PDN-21

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Considered an unlikely route of entry in commercial/industrial environments.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  Respiratory sensitization may result in allergic/asthma like responses; from coughing and minor breathing difficulties to bronchitis with wheezing, gasping.  

CHRONIC HEALTH EFFECTS

  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  

  Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust.  Exposure to small quantities may induce hypersensitivity reactions characterized by acute bronchospasm, hives (urticaria), deep dermal wheals (angioneurotic edema), running nose (rhinitis) and blurred vision . Anaphylactic shock and skin rash (non-thrombocytopenic purpura) may occur. An individual may be predisposed to such anti-body mediated reaction if other chemical agents have caused prior sensitization (cross-sensitivity).