Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

KANAMYCIN B SULFATE

NFPA

PRODUCT USE

An aminoglycoside antibiotic which acts by inhibiting protein synthesis in susceptible
bacteria. Active against many strains of Gram- negative bacteria and Gram- positive
Staphylococcus aureus and epidermis. Some strains of Mycobacterium bacterium are
sensitive. Most active in alkaline solution.

SYNONYMS

C18-H37-N5-O10.H2SO4, "D-streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-
(2, 6-diamino-2, 6-dideo-alpha-D-glucopyranosyl)-(1->4)-2-deoxy-, sulfate (1:1)", "D-
streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(2, 6-diamino-2, 6-dideo-
alpha-D-glucopyranosyl)-(1->4)-2-deoxy-, sulfate (1:1)", "aminodeoxykanamycin sulfate",
"bekanamycin sulfate", "kanamycin B, sulfate (1:1) salt", "kanendomycin sulfate",
"antibiotic/ antibacterial/ aminoglucoside/ aminoglycoside"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  The dust may produce eye discomfort causing smarting, pain and redness.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Open cuts, abraded or irritated skin should not be exposed to this material.  Toxic effects may result from skin absorption.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are by accidental skin and eye contact andinhalation of generated dusts.  Long-term exposure to aminoglycoside antibiotics (such as gentamicin) can damage the kidneys and malabsorption with a fatty, foul-smelling diarrhea. In some patients, there may be hearing loss and damage to the balancing system, after topical application or injection. Respiratory depression and paralysis of muscle has also been caused by this class of antibiotic. Some patients may display visual hallucinations, multiple nerve disorders and brain damage. Especially in those patients receiving cancer chemotherapy, there may be electrolyte imbalance in the blood following long-term use (reduced magnesium, calcium and potassium).