Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HALOFENOZIDE

NFPA

PRODUCT USE

Insecticide. Ecdysone agonist which acts by binding to the ecdysone receptor protein.
Ecdysones are insect hormones which control the process of metamorphosis as the insects
pass from larva to pupa to adult. Metamorphosis requires the careful synchrony of many
hormones and other physiological changes to be successful and tebufenozide seems to be an
" ecdysone blocker" that blocks the insect' s production and release of vital hormones.
Insects then, will not molt thus breaking their normal life- cycle.

SYNONYMS

C18-H19-Cl-N2-O2, N-tert-butyl-N'-(4-chlorobenzoyl)benzohydrazide, N-tert-butyl-N'-(4-
chlorobenzoyl)benzohydrazide, "4-chloro-2-benzoyl-2-(1, 1-dimethylethyl)hydrazide", "4-
chloro-2-benzoyl-2-(1, 1-dimethylethyl)hydrazide", "Mach 2", RH-0345, "ecdysone/
ecdysteroid blocker/ insecticide/ pesticide", "diacylhydrazine/ biacylhydrazine"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

None

EMERGENCY OVERVIEW

RISK

Harmful to aquatic organisms, may cause long- term adverse effects in the
aquatic environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Considered an unlikely route of entry in commercial/industrial environments.  The acute toxicity of the bisacylhydrazines to higher organisms is reportedly low. They are however significantly liphophilic and may affect membrane structure and function. They have been reported to produce excitotoxicity in some insects by partitioning into membranes and blocking potassium ion channels, a mechanism which is independent of ecdysteroid activity. Thus the potential for neurotoxicity should be recognised.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  The material may produce moderate eye irritation leading to inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's edema. The pathogenesis of contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the delayed type. Other allergic skin reactions, e.g. contact urticaria, involve antibody-mediated immune reactions. The significance of the contact allergen is not simply determined by its sensitization potential: the distribution of the substance and the opportunities for contact with it are equally important. A weakly sensitizing substance which is widely distributed can be a more important allergen than one with stronger sensitizing potential with which few individuals come into contact. From a clinical point of view, substances are noteworthy if they produce an allergic test reaction in more than 1% of the persons tested.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust.