Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

LAVENDUSTIN A METHYL ESTER

NFPA

PRODUCT USE

Cell permeable inhibitor of tyrosine kinase with little effect on protein kinase A or C;
inhibits NMDA- stimulated c- GMP production.

SYNONYMS

C22-H21-N-O6, C22-H21-N-O6, "benzoic acid, 5-[((2, 5-dihydroxyphenyl)methyl)((2-
hydroxyphenyl)methyl)-amino]-2'-hydroxy-, methyl ester", "benzoic acid, 5-[((2, 5-
dihydroxyphenyl)methyl)((2-hydroxyphenyl)methyl)-amino]-2'-hydroxy-, methyl ester", "5-
[((2, 5-dihydroxybenzyl)((2-hydroxybenzyl)methyl)]aminosalicylic acidmethyl ester", "5-
[((2, 5-dihydroxybenzyl)((2-hydroxybenzyl)methyl)]aminosalicylic acidmethyl ester",
"tyrosine/ protein kinase inhibitor"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Considered an unlikely route of entry in commercial/industrial environments.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  

INHALED

  The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust.  The material may inhibit protein kinase. This family of kinases enzymatically catalyses the phosphorylation of protein . Because phosphorylation triggers a signaling cascade which in turn produces cell growth, inhibition effectively retards the process. There are several different inhibitors which act in this manner but most common are genistein (a naturally occurring steroid-like substance from soybeans), lavendustin (a microbial metabolite) and the tyrphostins (synthetic analogues).  Two families of protein kinase have been identified;  · serine-threonine kinases (also known as PKC) require calcium ion for their activation. The activated PKC phosphorylates proteins of the cellular signal cascade, which eventually induce expression of growth regulatory genes.  · tyrosine kinases which similarly regulate signal transmission to growth regulatory genes  Inhibition may suppress cell or tissue growth or development.