Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

M-CRESYL GLYCIDYL ETHER

NFPA

PRODUCT USE

Monomer. Drug

SYNONYMS

C10-H12-O2, "cresyl glycidyl ether", "glycidyl 3-methylphenyl ether", "glycidyl 3-
methylphenyl ether", "propane, 1, 2-epoxy-3-(m-tolyloxy)-", "propane, 1, 2-epoxy-3-(m-
tolyloxy)-", "1, 2-epoxy-3-(m-tolyloxy)propane", "1, 2-epoxy-3-(m-tolyloxy)propane",
"glycidyl m-methylphenyl ether", "glycidyl m-methylphenyl ether", "glycidyl m-tolyl
ether", "glycidyl m-tolyl ether", [m-(tolyloxy)methyl]oxirane, "2, 3-epoxypropyl-m-tolyl
ether", "2, 3-epoxypropyl-m-tolyl ether", ((3-methylphenoxy)methyl)oxirane, 2-((3-
methylphenoxy)methyl)oxirane, 2-((3-methylphenoxy)methyl)oxirane, "4-methylphenyl
glycidyl ether", "4-methylphenyl glycidyl ether", "oxirane, (( 4-methylphenoxy)methyl)-",
"oxirane, (( 4-methylphenoxy)methyl)-"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

May form explosive peroxides.
Irritating to skin.
May cause SENSITIZATION by skin contact.
Possible risk of irreversible effects.
Toxic to aquatic organisms, may cause long- term adverse effects in the aquatic
environment.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Strong evidence exists that the substance may cause irreversible but non-lethal mutagenic effects following a single exposure.  The material has NOT been classified as "harmful by ingestion". This is because of the lack of corroborating animal or human evidence. The material may still be damaging to the health of the individual, following ingestion, especially where pre-existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, unintentional ingestion is not thought to be cause for concern.  

EYE

  Although the liquid is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  This material can cause inflammation of the skin oncontact in some persons.  The material may accentuate any pre-existing dermatitis condition.  Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.  Open cuts, abraded or irritated skin should not be exposed to this material.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  

INHALED

  The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified using animal models). Nevertheless, adverse effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.  Inhalation hazard is increased at higher temperatures.  Not normally a hazard due to non-volatile nature of product.  

CHRONIC HEALTH EFFECTS

  Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population.  Exposure to the material may result in a possible risk of irreversible effects. The material may produce mutagenic effects in man. This concern is raised, generally, on the basis ofappropriate studies using mammalian somatic cells in vivo. Such findings are often supported by positive results from in vitro mutagenicity studies.  There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment.  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  Glycidyl ethers can cause genetic damage and cancer.  Respiratory sensitization may result in allergic/asthma like responses; from coughing and minor breathing difficulties to bronchitis with wheezing, gasping.