Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

VALONE

NFPA

PRODUCT USE

Anticoagulant rodenticide; insecticide.

SYNONYMS

C14-H14-O3, "1, 3-indandione, 2-pivaloyl-", "1, 3-indandione, 2-pivaloyl-", "1, 3-
indandione, 2-isovaleryl-", "1, 3-indandione, 2-isovaleryl-", "2-isopentanoyl-1, 3-
indanedione", "2-isopentanoyl-1, 3-indanedione", "isovaleryl indanedione", "2-
isovalerylindan-1, 3-dione", "2-isovalerylindan-1, 3-dione", "2-isovaleryl-1, 3-
indandione", "2-isovaleryl-1, 3-indandione", "2-isovaleryl-1, 3-indanedione", "2-
isovaleryl-1, 3-indanedione", Isoval, "Motomco Tracking Powder", PMP, "anticoagulant
rodenticide insecticide"

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  Heparin, coumarin and indan-1,3-dione derivatives are used to kill rodents and to prevent blood clotting. They block the synthesis of prothrombin by antagonizing vitamin K. They are safe in normal use but with high does or prolonged use, they can cause bleeding accidents, especially in sensitive persons. Symptoms of poisoning include nausea and vomiting; effects may be delayed for days. Other symptoms include bleeding gums, easy bruising, blood in the urine and excessive bleeding from minor wounds. Severe poisonings can cause shock, coma and death.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.  The material is not thought to be a skin irritant (as classified using animal models). Temporary discomfort, however, may result from prolonged dermal exposures. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Bare unprotected skin should not be exposed to this material.  Coumarin and its derivatives may act as slight allergens in contact withskin.  

INHALED

  Inhalation may produce health damage*.  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of the material, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  Coumarin and its derivatives may act as slight allergens in contact withmucous membranes. Absorption by the lungs is not considered to be asignificant route of entry.  

CHRONIC HEALTH EFFECTS

  There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.  

  Principal routes of exposure are usually by inhalation of generated dust and skin contact/absorption.  Clinical use of indandiones has shown diarrhoea, pyrexia, renal  tubular necrosis, paralysis of accommodation and exfoliative dermatitis.  Repeated exposure to some coumarin derivatives may cause nosebleed, bleeding gut and pharynx, dark red bleeding spots, widespread bruising, blood swelling, blood in the phlegm, vomitus, urine or stools. Bleeding into the organs, digestive tract, joints, abdomen can cause localized pain. Exposure at work can cause anemia with weakness, pallor and shock. Many coumarins cause mutations and cancer. Coumarins also inhibit tumor production by carcinogens and inhibit metastasis.