Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME

HEXAMETHYLENEDIAMINE, MELT

NFPA

PRODUCT USE

Intermediate in the manufacture of nylon. Also used as a spacer in affinity
chromatography.

SYNONYMS

C6-H16-N2, NH2-(CH2)6-NH2, HMDA, "hexane, 1, 6-diamino-", "hexane, 1, 6-diamino-", "1,
6-diaminohexane", "1, 6-diaminohexane", hexamethylenediamine, "1, 6-hexamethylenediamine",
"1, 6-hexamethylenediamine", "1, 6-hexanediamine", "1, 6-hexanediamine", NCI-61405,
alkylamine

Section 2 - HAZARDS IDENTIFICATION

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Causes burns.
Risk of serious damage to eyes.
Harmful in contact with skin and if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion.  Amines without benzene rings when swallowed are absorbed throughout the gut. Corrosive action may cause damage throughout the gastrointestinal tract. They are removed through the liver, kidney and intestinal mucosa by enzyme breakdown.  

EYE

  The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating.  If applied to the eyes, this material causes severe eye damage.  The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion.  The material can produce chemical burns following direct contactwith the skin.  

SKIN

  Skin contact with the material may be harmful; systemic effects may resultfollowing absorption.  The material can produce chemical burns following direct contactwith the skin.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion.  The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating.  

INHALED

  Inhalation of aerosols (mists, fumes), generated by the material during the course of normal handling, may produce serious damage to the health of the individual.  The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.  Processing for an overly long time or processing at overly high temperatures may cause generation and release of highly irritating vapors, which irritate eyes, nose, throat, causing red itching eyes, coughing, sore throat.  Inhalation of amine vapors may cause irritation of the mucous membrane of the nose and throat, and lung irritation with respiratory distress and cough. Swelling and inflammation of the respiratory tract is seen in serious cases; with headache, nausea, faintness and anxiety There may also be wheezing.  

CHRONIC HEALTH EFFECTS

  Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems.  Repeated or prolonged exposure to corrosives may result in the erosion of teeth, inflammatory and ulcerative changes in the mouth and necrosis (rarely) of the jaw. Bronchial irritation, with cough, and frequent attacks of bronchial pneumonia may ensue. Gastrointestinal disturbances may also occur. Chronic exposures may result in dermatitis and/or conjunctivitis.  Maternally toxic doses given orally on day 7 through day 16 of gestation  produced foetotoxicity as evidenced by retarded weight gain and skeletal  development (184 mg/kg doses level). No evidence for a teratogenic  response was observed at levels up to 300 mg/kg.